logo
Share SHARE
FONT-SIZE Plus   Neg

Myriad Genetics Study Finds High Prevalence Of Mutations In The PMS2 Gene

Myriad Genetics Inc. (MYGN) announced that a presentation entitled, "Representation of PMS2 mutations in patients seeking genetic testing for Lynch syndrome," was presented at the 2012 American College of Medical Genetics and Genomics or ACMG Annual Clinical Genetics Meeting.

The company said that the study found cancer causing mutations in the PMS2 gene in 14 percent of patients with personal and family histories suggestive of Lynch syndrome, a hereditary form of colon cancer. The study concluded that comprehensive diagnostic testing for Lynch syndrome should include the PMS2 gene.

Researchers at Myriad analyzed the prevalence of genetic mutations using the COLARIS test in 327 patients to confirm the importance of testing for mutations in the PMS2 gene. Cancer causing mutations were also found in the MSH2, MLH1, and MSH6 genes. Approximately 38 percent of patients were found to have a mutation in the MSH2 gene, 30 percent in the MLH1 gene, 18 percent in the MSH6 gene and 14 percent of mutations were found in the PMS2 gene, the company said.

The company noted that the study demonstrates the importance of the analyzing the PMS2 gene to fully comprehend a patient's Lynch syndrome status.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Computer and printer maker Hewlett-Packard Co. said Thursday after the markets closed that its second quarter profit fell 21% from last year, hurt by lower revenue and costs related to the planned separation of the company. However, the company's quarterly earnings per share, excluding items, came in above analysts' expectations, but its quarterly revenue fell short of analysts' forecast. Accounting software maker Intuit reported a plunge in third-quarter profit, hurt by impairment charges, even as results topped Wall Street estimates, driven by growth in small business segment amid a strong tax season. Struggling teen-apparel retailer Aeropostale Inc. (ARO), Thursday said its first-quarter loss narrowed from a year ago, driven largely by stronger margins even as revenues continued to plunge dropped. Nevertheless, the company lost almost one-fifth of its market value in after-hours trade, with the...
comments powered by Disqus
RELATED NEWS
Trade MYGN now with 
Follow RTT