Quick Facts
FONT-SIZE Plus   Neg
Share SHARE

StemCells' Phase I Trial In PMD Shows Evidence Of Progressive Myelination

RELATED NEWS
Trade STEM now with 

StemCells, Inc. (STEM: Quote) revealed preliminary evidence of progressive and durable donor-cell derived myelination in all four patients who underwent transplantation with the company's proprietary HuCNS-SC cells in its clinical trial for Pelizaeus-Merzbacher disease, or PMD, a rare hypo-myelination disorder in children.

In addition, clinical assessment disclosed small but measureable gains in motor and/or cognitive function in three of the four patients; the fourth patient remained clinically stable.

The company noted that the open-label Phase I trial enrolled four patients with the connatal form of PMD, between the ages of 14 months and 5 years, and was designed to assess safety and preliminary efficacy of the intervention. The study used magnetic resonance, or MR, imaging, commonly employed in other neurological diseases, to explore signs of myelination related to the transplanted neural stem cells.

At the one-year interval, MR imaging showed changes compatible with increased myelination in the region of the transplantation.

Further, the company said that a separate four-year observational study will continue to monitor and report the future progress for all four patients.

"The finding of myelin formation in this first exploratory study is indeed very encouraging," said Stephen Huhn, Vice President and Head of the CNS Program at StemCells, Inc. "We believe that the results of this trial provide proof-of-concept and a compelling rationale for the Company to begin planning for a controlled Phase II study in PMD. These results may also have implications for other leukodystrophies, as well as more common myelin disorders including transverse myelitis, multiple sclerosis and periventricular white matter injury seen in Cerebral Palsy..."

Register
To receive FREE breaking news email alerts for StemCells Inc and others in your portfolio

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
This apparel maker has doubled its earnings per share in just two years and increased its annual earnings forecast from time to time, despite a challenging consumer spending environment. Contributions from acquisitions, efficiency gains from self-owned global supply chain and benefits from 'Innovate-to-Elevate' strategy continue to boost the company's results. Here is a quick summary of the earnings reported after the bell on Nov 20. We have 20+ stocks listed here. The good news is you can skip this step. There is a next move that can make your life a lot easier. Our research team has already done the groundwork for you. All these stocks listed... Design software maker Autodesk, Inc. said Thursday after the markets closed that its third quarter profit fell 81% from last year, as higher costs and expenses more than offset an 11% increase in revenue. However, the company's quarterly earnings per share, excluding items, came in above analysts' expectations as did its quarterly revenue.
comments powered by Disqus
FREE Newsletters, Analysis & Alerts

 

Stay informed with our FREE daily Newsletters and real-time breaking News Alerts. Sign up to receive the latest information on business news, health, technology, biotech, market analysis, currency trading and more.