logo
Share SHARE
FONT-SIZE Plus   Neg

StemCells' Phase I Trial In PMD Shows Evidence Of Progressive Myelination

StemCells, Inc. (STEM) revealed preliminary evidence of progressive and durable donor-cell derived myelination in all four patients who underwent transplantation with the company's proprietary HuCNS-SC cells in its clinical trial for Pelizaeus-Merzbacher disease, or PMD, a rare hypo-myelination disorder in children.

In addition, clinical assessment disclosed small but measureable gains in motor and/or cognitive function in three of the four patients; the fourth patient remained clinically stable.

The company noted that the open-label Phase I trial enrolled four patients with the connatal form of PMD, between the ages of 14 months and 5 years, and was designed to assess safety and preliminary efficacy of the intervention. The study used magnetic resonance, or MR, imaging, commonly employed in other neurological diseases, to explore signs of myelination related to the transplanted neural stem cells.

At the one-year interval, MR imaging showed changes compatible with increased myelination in the region of the transplantation.

Further, the company said that a separate four-year observational study will continue to monitor and report the future progress for all four patients.

"The finding of myelin formation in this first exploratory study is indeed very encouraging," said Stephen Huhn, Vice President and Head of the CNS Program at StemCells, Inc. "We believe that the results of this trial provide proof-of-concept and a compelling rationale for the Company to begin planning for a controlled Phase II study in PMD. These results may also have implications for other leukodystrophies, as well as more common myelin disorders including transverse myelitis, multiple sclerosis and periventricular white matter injury seen in Cerebral Palsy..."

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Maternity leave is a temporary period of absence from employment granted to expectant or new mothers during the months immediately before and after their pregnancy. Parental leave, including maternity, paternity and adoption leave, is an employee benefit. Many countries around the world, including... Texas, the second largest state in the U.S., has four of the five fastest-growing cities in the U.S., according to new population estimates released Thursday by the U.S. Census Bureau for the twelve months up to July 1, 2016. Ten of the fifteen fastest growing large U.S. cities during that 12-month span were in the South, according to the Census Bureau. To book-lover's surprise, online retailer Amazon opened another bricks and mortar store in an upmarket shopping mall in New York. This is the seventh book store of Amazon.
comments powered by Disqus
Follow RTT