logo
Share SHARE
FONT-SIZE Plus   Neg

Aeterna Zentaris Says AEZS-136 Showed Synergy, Efficacy In Human Tumor Cells

Aeterna Zentaris Inc. (AEZS, AEZ.TO) said that a poster on its novel orally active anticancer PI3K/Erk 1/2 inhibitor, AEZS-136, showed the compound's unique inhibition and excellent activity against PI3K and Erk signaling pathways, as well as being well tolerated.

According to the company, AEZS-136 was well tolerated and showed dose-dependent inhibition of human colon tumor growth of up to 72% in a Hct116 mouse model.

Aeterna Zentaris noted that the anti-proliferative efficacy of AEZS-136 was evaluated in more than 40 human tumor cell lines including breast, ovary, endometrium, multiple myeloma, lung, melanoma, colon, leukemia and prostate cancer cells. In vitro ADMET properties were also widely assessed, while in vivo pharmacokinetics and anti-tumor efficacy was explored.

Juergen Engel, Aeterna Zentaris' President and CEO, commented, "The preclinical data presented yesterday, confirms that AEZS-136 has a unique advantageous dual PI3K /Erk kinase inhibition profile which could prove to be more efficient than single pathway inhibition. Furthermore, AEZS-136 has shown to be well tolerated.

Following these encouraging preclinical data, we are currently moving this promising compound into the clinical development stage."

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Apple has upgraded the data storage option for its online storage service iCloud Drive, now offering 2 terabytes of space for $19.99 a month. The move reportedly indicates a new storage tier for the upcoming iPhone 7, which is set to be launched on September 7, along with the larger iPhone 7 Plus. Shares of Karyopharm Therapeutics Inc. (KPTI) soared over 36% on Tuesday after the company said it will provide an overview of top-line results from its Phase 2b study for oral Selinexor in multiple myeloma, dubbed STORM, on September 6, 2016. Chipotle Mexican Grill (CMG) is giving away free food and drinks this September as the restaurant chain still struggles to boost its sales that has been sluggish after outbreaks of E.coli, salmonella and norovirus at its restaurants. The chain is offering free kids meals every Sunday in September...
comments powered by Disqus
Follow RTT