Quick Facts
FONT-SIZE Plus   Neg
Share SHARE

Amgen Reports Top-Line Results Of Phase 3 Sensipar/Mimpara EVOLVE Trial

RELATED NEWS
Trade AMGN now with 

Amgen Inc. (AMGN: Quote) announced top-line results of the Phase 3 EVOLVE trial, evaluating Sensipar/Mimpara for the reduction of the risk of mortality and cardiovascular or CV events among 3,883 patients with secondary hyperparathyroidism and chronic kidney disease receiving dialysis.

The trial's primary endpoint was time to the composite event comprising all-cause mortality or first non-fatal cardiovascular event, including myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event. Though patients in the Sensipar/Mimpara arm experienced numerically fewer composite primary events, the results were not statistically significant, and the study failed to meet its primary endpoint in the intent-to-treat analysis.

"Amgen embarked on the EVOLVE trial to understand whether treating secondary HPT with Sensipar/Mimpara could positively impact the high rates of mortality and cardiovascular events among patients with CKD receiving dialysis," said Sean Harper, M.D., executive vice president of Research and Development at Amgen.

The most frequently reported adverse events in the Sensipar/Mimpara arm of the trial were consistent with the known safety profile of this therapy and included nausea, vomiting and hypocalcemia.

Register
To receive FREE breaking news email alerts for Amgen Inc. and others in your portfolio

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Testosterone, often considered as the "fountain of youth", is the major sex hormone in men, and as they age the level of this hormone also naturally declines. The condition in which the body doesn't produce enough testosterone is known as hypogonadism or simply, Low T. European Central Bank Executive Board Member Benoit Coeure and a Germany's Deputy Labor Minister Joerg Asmussen have urged Germany to cut taxes on wages and promote investment to revive the euro area economy. In a jointly-authored opinion piece for the German daily Berliner Zeitung and the French... In a historic referendum to decide whether Scotland should become independent from the United Kingdom, majority of voters polled against it. In a vote that saw an unprecedented turnout Thursday, the campaign in favor of Scotland remaining in the UK, "Better Together", received 2,001,926 votes, or 55 percent. The campaign in favor of Scottish independence, called "Yes Scotland", had the support o
comments powered by Disqus
FREE Newsletters, Analysis & Alerts

 

Stay informed with our FREE daily Newsletters and real-time breaking News Alerts. Sign up to receive the latest information on business news, health, technology, biotech, market analysis, currency trading and more.