FONT-SIZE Plus   Neg

Shire's VPRIV Shows Improvement In Gaucher-Related Bone Disease - Quick Facts

Shire plc (SHP.L,SHPGY) reported new data that demonstrate velaglucerase alfa for injection or VPRIV, the company's enzyme replacement therapy for type 1 Gaucher disease, significantly improved selected markers of Gaucher-related bone disease in patients. The data presented show that VPRIV improves Gaucher-related bone disease by a sustained increase in bone mineral density or BMD.

Results from a head-to-head Phase III study of VPRIV and Cerezyme, and follow-on extension trial of VPRIV, show a statistically significant improvement in lumbar spine BMD in Gaucher patients starting at nine months of treatment with VPRIV. Clinically and statistically significant improvement from baseline in mean LS Z-score was witnessed at 9 months of treatment with VPRIV, but not in the cohort of patients treated with Cerezyme.

In Gaucher disease patients, BMD is generally reduced compared to individuals without Gaucher disease, often resulting in lower Z-scores.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Apple confirmed that it has bought face animation software firm Faceshift, although it was tight lipped about how it intends to use the new addition. The move is speculated as a bid to expand into virtual reality. Environment ministry of South Korea Thursday ordered Volkswagen Korea to recall 125,522 diesel vehicles on determining actual emissions of nitrogen oxides. The ministry has asked the German automobile maker to pay a fine of 14.1 billion Won or $12.31 million. The company has to submit a recall plan by January 6, 2016. The U.S. Food and Drug Administration has alerted health care professionals and patients of a voluntary recall of compounded multivitamin capsules containing high amounts of Vitamin D3 (Cholecalciferol), distributed nationwide by Glades Drugs in Pahokee, Florida. FDA has received reports of several...
comments powered by Disqus
Follow RTT