logo
Share SHARE
FONT-SIZE Plus   Neg

GlaxoSmithKline, Theravance Say Lung Disease Treatment Showed Positive Results

British drug giant GlaxoSmithKline Plc (GSK: Quote, GSK.L) and US biopharma firm Theravance Inc. (THRX: Quote) Monday said that four pivotal phase III studies of their investigational combination drug showed statistically significant improvements in patients with chronic obstructive pulmonary disease, or COPD.

Once-daily LAMA/LABA is a combination of two investigational bronchodilator molecules, which GlaxoSmithKline is developing with Theravance. Subject to successful completion of the ongoing studies, the companies plan to commence global regulatory filings from the end of this year.

GlaxoSmithKline said the studies involved over 4,000 patients with COPD, which had two 24-week efficacy studies that compared the combination LAMA/LABA, its components and placebo. The two 24-week active comparator studies compared the combination with the LAMA, long-acting muscarinic antagonist, tiotropium - a widely prescribed maintenance bronchodilator for COPD.

The first 24-week study involved 1,493 patients and the second 24-week study randomised 1,536 patients. Both showed statistically significant improvements.

In active comparator efficacy studies, the first 24-week study randomised 846 patients and the second 24-week study randomised 872 patients. These studies also resulted in a statistically significant improvement in patients with COPD.

COPD makes breathing difficult and is mainly caused by smoking all though it occurs in non-smokers too. According to reports, more than 12 million American adults suffer from COPD, and another 12 million Americans likely have this lung disease without knowing it.

GSK.L is currently trading at 1,449 pence, up 2 pence or 0.14 percent, on a volume of 1.91 million shares o the LSE. In US, GSK closed Friday's regular trading at $45.57 om the NYSE.

THRX ended on Friday at $22.22 on the Nasdaq.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Editors Pick
Hewlett-Packard Co. (HPQ) has filed a lawsuit against Michael Lynch, the co-founder of Autonomy Corp., and its former Financial Chief Sushovan Hussain for a whopping $5.1 billion alleging that the executives misrepresented the financial situation of Autonomy. An HP's spokeswoman confirmed that the... Nine acres of green grass with 400 trees and a half-mile-long walk way. We are not talking about any park, but the expansive rooftop of Facebook's new office. The 430,000 square feet office is a single room and it might be the largest open floor plan in the world. Outrage in the business world may be helping re-shape a new Indiana law that many are calling "anti-gay." Embarrassed and worried about the backlash from the national business community, the state's paper of record is loudly calling on legislators to re-word the law. The front page of the Indianapolis...
comments powered by Disqus
RELATED NEWS
Trade GSK now with 
Follow RTT