logo
Share SHARE
FONT-SIZE Plus   Neg

Merck KgaA Inks License Agreement With Symphogen On Sym004 - Update

Merck KGaA (MKGAY.PK) said Thursday that an exclusive worldwide license agreement was signed with Copenhagen, Denmark-based Symphogen A/S for Sym004, an investigational antibody mixture targeting the epidermal growth factor receptor or EGFR.

As per the agreement, Merck will gain exclusive worldwide rights to develop and commercialize Sym004 and will pay Symphogen 20 million euros upfront. Merck will also make payments to Symphogen for clinical development, regulatory and sales performance milestones. Symphogen will also be eligible for potential royalties on net worldwide sales.

Sym004 is comprised of two antibodies that are designed to block ligand binding, receptor activation and downstream signaling. They are also thought to elicit removal of the EGFR receptors from the cancer cell surface by inducing EGFR internalization and degradation.

Sym004 is currently being evaluated in a Phase I/II trial for the treatment of patients with advanced KRAS wild-type metastatic colorectal cancer or mCRC, who have previously progressed on treatment with standard chemotherapy and a marketed anti-EGFR monoclonal antibody.

Additionally, a single-arm, open-label Phase II trial in patients with squamous cell carcinoma of the head and neck, or SCCHN, who have failed anti-EGFR-based therapy is currently in progress.

Dr. Susan Jane Herbert, Head of Global Business Development and Strategy for the Merck Serono division, said, "Sym004 further strengthens our early development pipeline by adding a product that is thought to act via a proposed synergistic mechanism of action not previously studied, but more specifically, it has the potential to become a key asset complementing our already highly successful Erbitux franchise."

The stock closed up 0.79 percent in Frankfurt on Wednesday at 91.65 euros.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Editors Pick
German conglomerate Bayer AG said it has made an all-cash offer to acquire U.S. competitor Monsanto for $122 per share or an aggregate value of $62 billion. Bayer expects the deal to reinforce it as a Life Science company with a deepened position. Responding to recent media reports, agricultural products giant Monsanto recently had disclosed that it had received an unsolicited proposal from Bayer. Agricultural machinery maker Deere & Co. reported Friday lower profit in its second quarter, reflecting weak equipment sales. Profit and net sales, however, topped analysts' estimates. Further, the company cut its forecast for fiscal 2016 profit, while updated sales view. Failing to find a buyer, the bankrupt retailer Sports Authority decided to close its remaining stores, and the brand will cease to exist. Sports Authority, once the nation's largest sporting goods retailer, said it plans to conduct going-out-of-business sales at all of its locations that weren't already slated to close, according to a new bankruptcy court filing in Delaware.
comments powered by Disqus
Follow RTT