logo
Share SHARE
FONT-SIZE Plus   Neg

Novartis: Entresto Shows Metabolic Benefits For HFrEF Patients With Diabetes

Novartis (NVS) reported results of a new post-hoc analysis in a subgroup of patients with reduced ejection fraction heart failure (HFrEF) and diabetes suggesting that Entresto (sacubitril/valsartan) tablets improved glycemic control compared to enalapril. The findings are based on data from PARADIGM-HF, the largest clinical trial ever conducted in systolic heart failure. The company said, Entresto lowered HbA1c levels - a measure of average blood glucose levels for the past two to three months - after one year of treatment for systolic heart failure, and this effect was sustained over three years of study follow-up.

Entresto is indicated to reduce the risk of cardiovascular death and hospitalization for HF in patients with chronic systolic heart failure and reduced ejection fraction. It is not indicated to treat diabetes.

"These results show that in addition to its compelling cardiovascular efficacy, Entresto may have important metabolic benefits for HFrEF patients with diabetes," said Vasant Narasimhan, Global Head, Drug Development and Chief Medical Officer, Novartis.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Amazon would reportedly sell Google's Chromecast streaming adapter for this Christmas. The online retailer giant has banned the product from its site for the last two years and has presumably settle the issues. Though the product is not available for sale, it has listed 4K-capable Chromecast Ultra adapter. Europe's no-frills airline Ryanair recognized pilot union for a smooth holiday season ahead. The airline had a discussion with its pilots union in Britain, Germany, Italy, Spain, Ireland, Portugal to iron out the issues. The pilots working for Ryanair have been enjoying different status and many of them were reportedly not in the rolls as full timers. Shares of Hennes & Mauritz AB or H&M were plunging around 13 percent in Sweden after the retailer reported lower sales in its fourth quarter with weakness in H&M brand's physical stores. However, H&M brand's online sales and sales of the group's other brands continued to develop well, the company said.
comments powered by Disqus
Follow RTT