logo
Share SHARE
FONT-SIZE Plus   Neg

Novartis: Entresto Shows Metabolic Benefits For HFrEF Patients With Diabetes

Novartis (NVS) reported results of a new post-hoc analysis in a subgroup of patients with reduced ejection fraction heart failure (HFrEF) and diabetes suggesting that Entresto (sacubitril/valsartan) tablets improved glycemic control compared to enalapril. The findings are based on data from PARADIGM-HF, the largest clinical trial ever conducted in systolic heart failure. The company said, Entresto lowered HbA1c levels - a measure of average blood glucose levels for the past two to three months - after one year of treatment for systolic heart failure, and this effect was sustained over three years of study follow-up.

Entresto is indicated to reduce the risk of cardiovascular death and hospitalization for HF in patients with chronic systolic heart failure and reduced ejection fraction. It is not indicated to treat diabetes.

"These results show that in addition to its compelling cardiovascular efficacy, Entresto may have important metabolic benefits for HFrEF patients with diabetes," said Vasant Narasimhan, Global Head, Drug Development and Chief Medical Officer, Novartis.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
10 Worst Places To Raise A Family Whether you are a young couple building a nest or seasoned parents looking for a change of scenery, there are number of places around the country that should be avoided, according to personal finance website WalletHub. They looked at mainly five categories for... A passenger has filed a lawsuit against Canadian budget airline Sunwing Airlines for serving him cheap sparkling wine instead of champagne on board a flight, according to media reports. The Canadian passenger, Daniel MacDuff, reportedly boarded his Sunwing flight to Cuba in February, on a flight package that advertised a complimentary on-board champagne toast. Senate Health Committee Chairman Lamar Alexander, R-Tenn., and ranking member Patty Murray, D-Wash., announced Thursday that twenty-two other Senators are cosponsoring their bipartisan plan to provide short-term stability to Obamacare. The bipartisan bill includes a two-year extension of the cost-sharing...
comments powered by Disqus
Follow RTT