logo
Plus   Neg
Share
Email

Novartis Announces Initiation Of SURPASS, Head-to-head Trial Of Cosentyx

Novartis announced the initiation of SURPASS, a head-to-head clinical trial of Cosentyx or secukinumab versus proposed biosimilar adalimumab in ankylosing spondylitis (AS). SURPASS is the first head-to-head clinical trial in AS investigating superiority of Cosentyx?in slowing spinal bone damage versus proposed biosimilar adalimumab. SURPASS is currently recruiting patients, with the?'first patient first visit' already achieved in November 2017.

SURPASS and EXCEED are part of a larger rheumatology program for Cosentyx. EXCEED is a head-to-head clinical trial of Cosentyx versus Humira(adalimumab) in psoriatic arthritis (PsA), which is already recruiting. EXCEED is the first large double-blinded head-to-head clinical trial versus Humira in PsA investigating superiority of Cosentyx on ACR 20 at 52 weeks as the primary endpoint.

Cosentyx is the first targeted biologic that specifically inhibits IL-17A, cornerstone cytokine involved in the inflammation of entheses in spondyloarthritis, which plays a major role in PsA and AS. Both conditions are debilitating autoimmune diseases with a high risk of mobility loss. Approximately 40 percent of PsA patients will develop irreversible joint damage and permanent physical deformity. For AS patients, inflammation of the sacroiliac joints and new bone formation of the spine is associated with increased levels of IL-17A, with severe cases progressing to irreversible spinal fusion.

by RTTNews Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Walmart Inc. has deepened its strategic partnership with Microsoft Corp. by choosing the technology giant as its preferred as well as strategic cloud provider and tap into the full range of Microsoft's cloud solutions. The five-year agreement brings together Amazon.com Inc.'s two major rivals. Walmart is Amazon's largest retail rival, while Microsoft is its biggest competitor in cloud computing. Goldman Sachs Group, Inc. on Tuesday reported a 44 percent surge in profit for the second quarter from last year, reflecting higher revenues across all segments. The company noted that revenues were the highest second-quarter revenue in nine years. Both revenue and earnings per share for the quarter beat analysts' expectations. The company's shares are down 0.4 percent in pre-market activity. Office sharing start-up WeWork said it will no longer serve meat at company events and also will not allow employee to expense meat. WeWork said it has made a commitment to be a meat-free organization. The company announced its meat-free policy in an internal memo to its global employees, saying that the move is intended to reduce the environmental impact of its business.
Follow RTT