logo
  

Genentech Announces "Groundbreaking" Alzheimer's Disease Prevention Trial

Genentech, an unit of Roche Group (RHHBY.PK), said Tuesday it will be part of the first-ever prevention trial in cognitively healthy individuals who are destined to develop Alzheimer's disease because of their genetic history.

Genetech said it will collaborate with the National Institutes of Health (NIH), Banner Alzheimer's Institute (BAI), and University of Antioquia in Colombia for the trial.

According to the company, the study - the first to investigate whether an anti-amyloid treatment can stave off the disease - will span two countries and help launch a new era of prevention research in the urgent fight against Alzheimer's.

The company said the $100 million trial is the cornerstone of a new international collaborative, the Alzheimer's Prevention Initiative (API), formed to accelerate the evaluation of promising but unproven prevention therapies.

The trial will probe an experimental anti-amyloid antibody treatment called crenezumab in approximately 300 people from an extraordinarily large extended family in Colombia, who share a rare genetic mutation that typically triggers Alzheimer's symptoms around age 45.

The trial will also include a smaller number of individuals in the U.S. The API team will collaborate with researchers from the NIH-supported Dominantly Inherited Alzheimer's Network (DIAN) to identify and recruit the U.S. participants.

The trial is designed to determine whether the drug can reduce participants' chances of developing the disease's disabling and irreversible symptoms, preserve memory and thinking abilities, and slow the progression of Alzheimer's biomarkers.

The company said that if crenezumab is shown to sustain memory and cognition in people certain to develop Alzheimer's, prevention trials could be designed to test it and other anti-amyloid drugs in a larger segment of the population.

If the treatment's effects on brain imaging and other biological measurements of the disease are shown to predict its clinical benefit, the study could establish a much more rapid way to test future therapies, it added.

According to Roche, about 5.4 million Americans are living with Alzheimer's today, a number expected to top 7.7 million by 2030. Globally, the disease and other dementias are expected to affect nearly 66 million by then.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
San Jose, California -based Demaiz Inc., doing business as Mex-tamale Foods, is recalling around 20,759 pounds of pork and beef tamales citing misbranding and undeclared allergen, the U.S. Department of Agriculture's Food Safety and Inspection Service or FSIS announced. The beef and pork tamale items produced between September 20 to October 14, 2021 contains sesame seeds, an allergen. McDonald's says equal pay for women is just the beginning, while conforming that the fast-food giant pays women globally 99.85 cents on the dollar for similar work, taking into account legitimate pay drivers such as level, location, experience, and performance. The company added that it is on track to close that identified gap in 2022. Verizon Communications Inc. (VZ) said, on an adjusted basis, its third-quarter earnings per share rose 12.8 percent from a year ago. The company said its earnings were highlighted by revenue and customer growth as more than one in four Consumer wireless phone customers now have a 5G-capable device. The...
Follow RTT