logo
Plus   Neg
Share
Email

StemCells Announces Positive Interim Data From Spinal Cord Injury Trial

StemCells Inc. (STEM) announced that interim six-month data from the first patient cohort in the company's Phase I/II clinical trial of its proprietary HuCNS-SC product candidate (purified human neural stem cells) for chronic spinal cord injury continues to demonstrate a favorable safety profile, and shows considerable gains in sensory function in two of the three patients compared to pre-transplant baselines. The third patient remains stable.

The trial represents the first time that neural stem cells have been transplanted as a potential therapeutic agent for spinal cord injury.

The company stated that Patients in the study's first cohort all suffered a complete injury to the thoracic (chest-level) spinal cord. In a complete injury, there is no neurological function below the level of injury. All three patients were transplanted four to nine months after injury with a dose of 20 million cells at the site of injury. The surgery, immunosuppression and the cell transplants have been well tolerated by all the patients.

There were no abnormal clinical, electrophysiological or radiological responses to the cells, and all the patients were neurologically stable through the first six months following transplantation. Changes in sensitivity to touch, heat and electrical stimuli were observed in well-defined and consistent areas below the level of injury in two of the patients, while no changes were observed in the third patient, the company said.

Importantly, tests of perception of different sensory stimuli as well as measures of electrical impulse transmission across the site of injury correlate with the clinical examination, providing independent and objective confirmation of the changes in sensory function.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Amazon Inc.'s shareholders are set to vote on two proposals related to the company's facial recognition system, Amazon Rekognition, at its annual general meeting in Seattle on Wednesday. Shareholders will first vote on whether the company should prohibit sales of Amazon Rekognition to government agencies. Amazon had attempted to block the votes. Home improvement retailer Lowe's Companies, Inc. (LOW) reported Wednesday a first-quarter net earnings of $1.05 billion or $1.31 per share, higher than $988 million or $1.19 per share in the prior-year quarter. Excluding a tax benefit and operating costs associated with the Mexico retail operations,... Morgan Stanley has cut its worst-case forecast on Tesla Inc.'s share price from the previous estimate of $97 to just $10, dealing another blow to the luxury electric car maker. The worst-case or "bear case" scenario by Morgan Stanley analysts takes into account the risk posed if Tesla misses its current sales outlook for China by about half.
Follow RTT