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Novo Nordisk: Tresiba Shows Lower Rate Of Hypoglycaemia Than Lantus

Novo Nordisk (NVO) announced the headline results from SWITCH 1, the second of two 2x32-weeks randomised, double-blind, cross-over, treat-to-target trials, comparing the safety and efficacy of Tresiba (insulin degludec) and Lantus (insulin glargine U100).

The company expects to initiate filing of the data from the SWITCH trials with regulatory authorities in third quarter of 2016 with the aim of updating the label for Tresiba.

The company noted that the trial met the primary end-point by demonstrating non-inferiority in the rate of severe or blood glucose confirmed symptomatic hypoglycemia of Tresiba compared to insulin glargine.

Novo Nordisk said Tresiba appeared to have a safe and well-tolerated profile.
Adverse events were comparable between the two treatment arms.

Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk, said, " We are very excited about these trial results, which document that Tresiba also in people with type 1 diabetes significantly reduces the risk of
hypoglycaemia compared to insulin glargine"

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