logo
Plus   Neg
Share
Email

Merck Announces Post-hoc Analysis From KEYNOTE-189 Trial - Quick Facts

Merck (MRK) announced the first-time presentation of results from a post-hoc analysis of patients with liver or brain metastases from the Phase 3 KEYNOTE-189 trial. In the primary analysis of KEYNOTE-189, which included patients regardless of PD-L1 expression status, KEYTRUDA in combination with pemetrexed and platinum chemotherapy resulted in a statistically significant and clinically meaningful improvement in overall survival, reducing the risk of death by half compared to chemotherapy alone. The study also showed a significant improvement in progression-free survival compared to chemotherapy alone, the company said.

Merck reported that the findings showed KEYTRUDA in combination with chemotherapy reduced the risk of death by 38 percent in patients with liver metastases and by 59 percent in patients with brain metastases compared to chemotherapy alone. KEYTRUDA in combination with chemotherapy also improved progression-free survival, with a reduction in the risk of progression or death by 48 percent in patients with liver metastases and 58 percent in patients with brain metastases compared to chemotherapy alone.

KEYNOTE-189 was conducted in collaboration with Eli Lilly and Company, the makers of pemetrexed.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
SiriusXM launched a new subscription package exclusively for college students at a steep discount, just ahead of the fall semester. The satellite-radio giant introduced the "Student Premier" Package that provides students with all the content in SiriusXM's "Premier Streaming" package for $4 per month. This is a 69 percent discount from the regular price of $12.99 per month for Premier Streaming. Apple Inc. warned that its newly launched titanium Apple Card can be easily damaged if not stored properly. The company advised that the card must be kept away from fabrics like leather and denim as they can cause permanent discoloration. The tech giant has posted a support page that provides instructions to users on how to protect and maintain their Apple Card. Southwire Co. LLC recalled about 3000 units of Garvin pop-up electrical outlet floor box kits for concerns of fire hazard. The company said the electrical receptacles can overheat when in use. Southwire already received three reports of the floor boxes overheating. However, there have been no injuries reported so far.
Follow RTT