logo
Plus   Neg
Share
Email

Merck: Phase 3 Trial Of BELSOMRA C-IV Meets Primary Efficacy Endpoints

Merck & Co Inc. (MRK) announced Tuesday that a Phase 3 trial evaluating the efficacy and safety of BELSOMRA (suvorexant) C-IV for the treatment of insomnia in people with mild-to-moderate Alzheimer's disease dementia met primary and secondary efficacy endpoints.

BELSOMRA is a first-in-class oral, highly selective antagonist for orexin receptors. The company noted that Orexin is a neurotransmitter found in a specific part of the brain that can help keep a person awake.

The Phase 3 randomized, double-blind, clinical trial evaluated the efficacy and safety of BELSOMRA (suvorexant) 10 mg. For the primary endpoint, 4-weeks of treatment with BELSOMRA improved mean total sleep time by 28.2 minutes versus placebo.

The company presents the results at the 2019 American Academy of Neurology Annual Meeting, held May 4-10 in Philadelphia, PA.

Merck noted that BELSOMRA C-IV 5 mg, 10 mg, 15 mg and 20 mg tablets are currently approved in the United States for treatment of insomnia characterized by difficulties with sleep onset and sleep maintenance.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
The United Auto Workers union on Sunday called for a strike at General Motors at midnight after both the parties failed to reach a tentative deal before a Saturday deadline. The last time the union declared a strike at GM was in 2007. General Motors has detailed its most recent offer, including 5,400 jobs and $7 billion in investment at its US plants. The United Auto Workers union reportedly plans to go on strike against auto giant General Motors Co. (GM) after both the parties failed to reach a tentative deal before a Saturday deadline. According to CNBC, the strike has been called despite GM saying it presented a "strong offer" to the union.... Millennials and Generation Zs, or people aged between 18 to 34 year, pay more for car repairs, according to a new survey. The average American spent $1,986 over the past five years on vehicle repairs and maintenance, according to a survey by Ally Financial conducted by Harris Poll. However, among...
Follow RTT