Plus   Neg

Merck: Phase 3 Trial Of BELSOMRA C-IV Meets Primary Efficacy Endpoints

Merck & Co Inc. (MRK) announced Tuesday that a Phase 3 trial evaluating the efficacy and safety of BELSOMRA (suvorexant) C-IV for the treatment of insomnia in people with mild-to-moderate Alzheimer's disease dementia met primary and secondary efficacy endpoints.

BELSOMRA is a first-in-class oral, highly selective antagonist for orexin receptors. The company noted that Orexin is a neurotransmitter found in a specific part of the brain that can help keep a person awake.

The Phase 3 randomized, double-blind, clinical trial evaluated the efficacy and safety of BELSOMRA (suvorexant) 10 mg. For the primary endpoint, 4-weeks of treatment with BELSOMRA improved mean total sleep time by 28.2 minutes versus placebo.

The company presents the results at the 2019 American Academy of Neurology Annual Meeting, held May 4-10 in Philadelphia, PA.

Merck noted that BELSOMRA C-IV 5 mg, 10 mg, 15 mg and 20 mg tablets are currently approved in the United States for treatment of insomnia characterized by difficulties with sleep onset and sleep maintenance.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Microsoft Corp. (MSFT) founder Bill Gates has admitted that his greatest mistake was allowing Google's android to become a dominant mobile operating system. Speaking at a Economic Club of Washington luncheon, Gates said to David Rubinstein on Monday, "We're in the field of doing operating systems... McDonald's said Monday that the introduction of fresh beef at its restaurants just over one year ago has helped it gain market share in the informal eating out or IEO category for the first time in five years. In May 2018, the burger chain switched to fresh beef quarter-pound burgers from frozen beef across the U.S., as part of its efforts to provide customers with a "hotter, juicer burger." 'Toy Story 4' has broken global office box records for an animated movie, according to media reports. The movie is the fourth instalment in the 'Toy Story' series and is the sequel to 2010's 'Toy Story 3.' The Disney and Pixar film has reportedly earned $238 million after opening worldwide over the weekend and performed particularly well in Latin America and Europe.
Follow RTT