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Amgen Reports Positive Data From AMG 510 Early Phase 1 Study - Quick Facts

Amgen (AMGN) said a Phase 1 study evaluating investigational AMG 510 showed anti-tumor activity when administered as a monotherapy in patients with locally-advanced or metastatic KRASG12C mutant solid tumors. There were no dose-limiting toxicities at tested dose levels. Regarding safety data from the phase 1 study, Amgen said treatment-related adverse events were primarily grade 1 events. Enrollment into dose expansion is underway.

AMG 510 is the first KRASG12C inhibitor to reach clinical stage. The first-in-human study enrolled 35 patients with various tumor types.

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