logo
Plus   Neg
Share
Email

AstraZeneca: Tagrisso Shows Positive OS Results In Phase III FLAURA Trial

AstraZeneca plc (AZN.L,AZN) announced Friday results of Phase III FLAURA trial showing that Tagrisso (osimertinib) significantly improves overall survival for 1st-line EGFR-mutated non-small cell lung cancer or NSCLC.

The randomised, double-blinded, multi-centre trial of Tagrisso was in previously-untreated patients with locally-advanced or metastatic NSCLC whose tumours have epidermal growth factor receptor or EGFR mutations.

Tagrisso showed a statistically-significant and clinically-meaningful improvement in OS, a secondary endpoint in the trial, compared with erlotinib or gefitinib both of which were previous standard-of-care treatments in this setting.

The company noted that Tagrisso is the only medicine demonstrating statistically-significant overall survival benefit in this setting. It also increased the time patients with central nervous system metastases lived without disease progression.

The FLAURA trial met its primary endpoint in July 2017, showing a statistically-significant and clinically-meaningful improvement in progression-free survival.

José Baselga, Executive Vice President, Oncology R&D said, "Today's positive results show that Tagrisso provides an unprecedented survival outcome versus previous standard-of-care epidermal growth factor receptor tyrosine kinase inhibitors, reaffirming Tagrisso as the 1st-line standard-of-care for EGFR-mutated metastatic non-small cell lung cancer."

AstraZeneca plans to present the OS results from the FLAURA trial at a forthcoming medical meeting.

Tagrisso is currently approved in 74 countries, including the US, Japan and the EU, for 1st-line EGFRm metastatic NSCLC.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
U.S. President Donald Trump said he discussed with Apple Inc.'s CEO Tim Cook about the impact of the U.S. tariffs on goods imported from China as well as the competition for Apple from South Korea's Samsung Electronics Co. Cook reportedly warned Trump that the tariffs on Chinese imports would hurt Apple's business as the tech giant relies heavily on manufacturing in China. Just Egg, a plant-based egg alternative, will be available in 2,100 stores owned by grocery chain Kroger Co. later this month. The product launch comes as plant-based meat and egg alternatives gain traction in the country. Just Egg, a product of California-based food technology company Just Inc., will be available at Kroger-owned stores, including Kroger, Fred Meyer and Ralphs. Boeing has delivered the first 787-10 Dreamliner to Vietnam Airlines, the flag carrier of Vietnam, as part of the eight 787-10 Dreamliner airplanes to be delivered on lease through Air Lease. Vietnam Airlines said the 787-10 Dreamliner, claimed by Boeing to be the most fuel-efficient twin-aisle airplane in the industry, will help it raise the customer experience on the Hanoi to Ho Chi Minh route.
Follow RTT