Plus   Neg

AstraZeneca: Tagrisso Shows Positive OS Results In Phase III FLAURA Trial

AstraZeneca plc (AZN.L,AZN) announced Friday results of Phase III FLAURA trial showing that Tagrisso (osimertinib) significantly improves overall survival for 1st-line EGFR-mutated non-small cell lung cancer or NSCLC.

The randomised, double-blinded, multi-centre trial of Tagrisso was in previously-untreated patients with locally-advanced or metastatic NSCLC whose tumours have epidermal growth factor receptor or EGFR mutations.

Tagrisso showed a statistically-significant and clinically-meaningful improvement in OS, a secondary endpoint in the trial, compared with erlotinib or gefitinib both of which were previous standard-of-care treatments in this setting.

The company noted that Tagrisso is the only medicine demonstrating statistically-significant overall survival benefit in this setting. It also increased the time patients with central nervous system metastases lived without disease progression.

The FLAURA trial met its primary endpoint in July 2017, showing a statistically-significant and clinically-meaningful improvement in progression-free survival.

José Baselga, Executive Vice President, Oncology R&D said, "Today's positive results show that Tagrisso provides an unprecedented survival outcome versus previous standard-of-care epidermal growth factor receptor tyrosine kinase inhibitors, reaffirming Tagrisso as the 1st-line standard-of-care for EGFR-mutated metastatic non-small cell lung cancer."

AstraZeneca plans to present the OS results from the FLAURA trial at a forthcoming medical meeting.

Tagrisso is currently approved in 74 countries, including the US, Japan and the EU, for 1st-line EGFRm metastatic NSCLC.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
The National Labor Relations Board ruled in favor of McDonald's in a long-running case filed by workers who accused the fast-food giant of retaliation after they tried to unionize. The lawsuit, filed by 20 employees against McDonald's and some of its franchise operators in 2015. The lawsuit was seeking a ruling that would consider McDonald's a 'joint employer' with its franchisees. Shares of Facebook fell almost 3 percent in Thursday's trading after the Wall Street Journal reported that the Federal Trade Commission is considering seeking a preliminary injunction against Facebook amid antitrust concerns over the company's integration of its apps. Facebook had earlier said it was planning to integrate its three messaging services. Beverages giant Pepsi announced the launch Pepsi Café, a new coffee-infused cola, which will debut in the United States in April 2020. The new beverage, which aims to satisfy both cola lovers and coffee fanatics across the US, comes in two delicious flavors - Original and Vanilla, with roasted Arabica coffee. It will be available at all major national retailers beginning in April next year.
Follow RTT