logo
Plus   Neg
Share
Email

Genome & Co. In Clinical Trial And Supply Deal With Merck KGaA, Pfizer

South Korea's Genome & Co. late Monday announced that it has entered into a clinical trial collaboration and supply agreement with Germany's Merck KGaA and US drug major Pfizer Inc.

The trial will evaluate the safety, tolerability, biological and clinical activities of GEN-001, Genome's microbiome-based immuno-oncology therapy, in combination with Merck KgaA and Pfizer's avelumab (BAVENCIO), a human anti-PD-L1 therapy, in multiple cancer indications.

Under the terms of the agreement, Genome & Co. will be the sponsor of the study. Merck KGaA and Pfizer will supply avelumab for the phase 1/1b clinical trial that is expected to be commenced in 2020 in the U.S. Both parties will have access to the clinical data.

The company expects to initiate the clinical trial in the coming months.

The combination trial is designed to be a first-in-human or FIH study including dose escalation and expansion cohorts to evaluate the safety and preliminary efficacy.

Avelumab in combination with axitinib is indicated in the US for the first-line treatment of patients with advanced renal cell carcinoma or RCC.

Avelumab is currently approved for patients within 50 countries globally. Majority of these approvals are in a broad indication that is not limited to a specific line of treatment.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Walt Disney Co.'s (DIS) streaming service Disney+ will be launched on March 24 in the UK and other markets in the Western Europe, one week earlier than originally planned on March 31. Pricing also been confirmed at 5.99 pounds/6.99 euros per month or 59.99 pounds/69.99 euros for an annual subscription.... Facebook plans to add 1,000 new jobs in the UK this year, with more than half of this focused on technology. The new jobs come ahead of Facebook's planned opening of its new office premises in King's Cross, London next year. It will take the social media giant's total employee count in the UK to more than 4,000 by the end of this year. E-commerce giant Amazon is planning to add 10,000 electric vehicles or EVs to its delivery fleet in India by 2025, as part of its efforts to combat the severe climate change. These vehicles are in addition to Amazon's plan of adding 100,000 electric vehicles in its global delivery fleet by 2030, as per the Climate Pledge, which it co-founded and signed in September 2019.
Follow RTT
>