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Novartis: Ofatumumab Data Show Efficacy, Safety In Treatment Of Multiple Sclerosis

Novartis (NVS) announced new ofatumumab data from the Phase III ASCLEPIOS trials and the Phase II APLIOS trial continue to demonstrate ofatumumab as a potential treatment option for patients with relapsing forms of multiple sclerosis. A post hoc analysis showed 47.0% and 87.8% of patients treated with ofatumumab achieved no evidence of disease activity (NEDA-3) within the first (0-12 months) and second year (12-24 months) of treatment, respectively. The safety profile was comparable to teriflunomide. Regulatory action for ofatumumab in the US is expected in June 2020.

Ofatumumab is a targeted B-cell therapy that, if approved, addresses a clinical unmet need as the first B-cell therapy that can be self-administered at home through an autoinjector pen.

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