logo
Plus   Neg
Share
Email

Janssen: Long-term Trial Shows TREMFYA As Efficacious Therapy In Plaque Psoriasis

Janssen Pharmaceutical Companies of Johnson & Johnson (JNJ) announced Monday new long-term plaque psoriasis data for TREMFYA (guselkumab).

The company noted that the first-in-class treatment showed consistent, high levels of skin clearance through four years in adult patients with moderate to severe plaque psoriasis.

In the open-label extension of VOYAGE 2, at four years, 80 percent of patients who were treated with guselkumab 100 mg every 8 weeks, achieved at least 90 percent improvement in the Psoriasis Area and Severity Index or PASI 90 score.

According to the company, Guselkumab is the first monoclonal antibody that selectively binds to the p19 subunit of IL-23, and inhibits its interaction with the IL-23 receptor, to have been approved by the European Commission.

Kristian Reichi, lead investigator of the VOYAGE 2 study, said, "Results from the VOYAGE 2 study demonstrate guselkumab as an efficacious therapy through four years, providing patients who may be experiencing chronic psoriatic symptoms with a long-term treatment option."

Separately, data from the randomised, placebo-controlled, head-to-head, Phase 3 VOYAGE 1 trial comparing patient-reported outcomes between those being treated with guselkumab and those being treated with adalimumab are also being shared online as a poster.

The new analysis show a higher proportion of patients treated with guselkumab reported symptom-free and sign-free status through 48 weeks versus adalimumab.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Former Google engineer Anthony Levandowski was sentenced by a U.S. judge to eighteen months in prison for stealing trade secrets from Google's self-driving car unit before he defected to Uber's rival unit. Levandowski admitted that from 2009 to 2016, he worked in Google's self-driving car program, known then as Project Chauffer. JetBlue has strengthened its face covering policy, by prohibiting face masks with vents or exhalation valves, starting August 10. It will also no longer allow customers to claim exemptions from wearing a face covering altogether. Home Depot, Inc. is set to open three new distribution centers in Georgia over the next 18 months, which is expected to create an additional 1,000 new jobs in Greater Atlanta, including full-time and part-time positions. The home improvement retailer has already created more than 5,000 new jobs in Georgia over the last five years.
Follow RTT