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Ascentage Collaborates With Acerta To Evaluate Combination Of Bcl-2 And BTK Inhibitors

Ascentage Pharma announced a clinical collaboration with Acerta Pharma, the hematology research and development center of excellence of AstraZeneca (AZN,AZN.L).

As the terms of the collaboration, Ascentage will sponsor a clinical trial to study the combination of Ascentage Pharma's APG-2575, a selective Bcl-2 inhibitor, and Acerta's CALQUENCE.

CALQUENCE is a Bruton's Tyrosine Kinase (BTK) inhibitor, evaluating the efficacy and safety of the combination therapy in patients with relapsed/refractory (r/r) chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).

CLL/SLL is a hematologic malignancy caused by mature B-cell neoplasms and constitutes the most common form of adult leukemia in North America and Europe, accounting for about 30% of all new leukemia cases.

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