logo
Plus   Neg
Share
Email

Pfizer Doses First Participant In Phase 3 BASIS Study Of Marstacimab - Quick Facts

Pfizer Inc. (PFE) said Monday that the first participant has been dosed in the Phase 3 BASIS study of marstacimab (PF-06741086), an anti-tissue factor pathway inhibitor or anti-TFPI being evaluated for the treatment of people with severe hemophilia A or B, with or without inhibitors.

BASIS is a global Phase 3, open-label, multicenter study that will evaluate annualized bleed rate or ABR through 12 months on prophylaxis treatment with marstacimab in adolescents and adults with hemophilia A or B, compared to a run-in period on replacement therapy with FVIII or FIX clotting factor, respectively, or bypass therapy.

The primary endpoint of the trial is the impact on ABR through 12 months following prophylaxis treatment with marstacimab. In addition, the incidence and severity of thrombotic events will be assessed.

According to the completed Phase 2 study results, treatment with marstacimab showed more than 75 percent reductions in ABR for all participants in the study population.

The participants were monitored in a long-term extension study, which showed sustained efficacy up to 12 months. In addition, no thrombotic events or treatment-related serious adverse events were observed in 20 participants receiving weekly subcutaneous marstacimab doses at or above the dose to be studied in the BASIS Phase 3 pivotal trial (300 mg subcutaneous loading followed by 150 mg subcutaneous weekly).

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Best Buy said it is partnering Popsockets to bring products designed by teens from the company's community programs to its store shelves. The electronics retailer will sell the teen-designed PopGrips in its stores as part of its "Black History Month" campaign. The campaign is intended to celebrate and encourage young artists. Goldman Sachs Group Inc. (GS) on Tuesday reported a fourth-quarter profit that more than doubled from last year, reflecting a surge in investment banking revenues and lower provisions for bad loans. Net revenues for the quarter rose 18 percent. Both quarterly earnings per share and revenues topped analysts' expectations. U.S. holiday retail sales in 2020 were unexpectedly high compared to last year and came in significantly higher than the previous forecast, according to the National Retail Federation or NRF. Retail sales for the November-December 2020 holiday season grew 8.3 percent from the prior-year period to $789.4 billion. The figures exclude automobile dealers, gasoline stations and restaurants.
Follow RTT