Plus   Neg

Merck : Keytruda Plus Lenvima Meets Primary Goal In Phase 3 Trial On Advanced Endometrial Cancer

Merck & Co Inc. (MRK) and Eisai said that phase 3 trial, which evaluated the investigational use of Keytruda plus Lenvima, met its dual primary endpoints of overall survival and progression-free survival and its secondary efficacy endpoint of objective response rate in patients with advanced endometrial cancer following at least one prior platinum-based regimen.

Merck's Keytruda is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells.

Lenvima is the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai.

The companies noted that Keytruda plus Lenvima demonstrated a statistically significant and clinically meaningful improvement in overall survival, progression-free survival and objective response rate versus chemotherapy. The safety profile of the Keytruda plus Lenvima combination was consistent with previously reported studies.

"..These are the first results from a Phase 3 trial of a combination regimen including immunotherapy in advanced endometrial carcinoma that have shown a statistically significant improvement in overall survival, progression-free survival and objective response rate versus chemotherapy, " said Gregory Lubiniecki, Associate Vice President, Oncology Clinical Research, Merck Research Laboratories.

The company noted that they are continuing to research the Keytruda plus Lenvima combination and discover new approaches to address unmet needs for devastating diseases such as endometrial carcinoma.

Keytruda is indicated for the treatment of patients with unresectable or metastatic melanoma.

Keytruda is indicated for the adjuvant treatment of patients with melanoma with involvement of lymph node(s) following complete resection.

Endometrial cancer begins in the inner lining of the uterus, which is known as the endometrium and is the most common type of cancer in the uterus.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Johnson & Johnson's (JNJ) Covid-19 vaccine is expected to be back on track as early as this weekend as a decision is expected after the advisory panel meeting of the U.S. Centers for Disease Control and Prevention (CDC) slated on April 23, according to Dr. Anthony Fauci, the chief medical adviser to President Joe Biden. MK-4482, the experimental antiviral drug for COVID-19, showed promise to prevent and treat SARS-CoV-2 infection in hamster study, according to the scientists of National Institutes of Health or NIH. The drug significantly decreased levels of virus and disease damage in the lungs of hamsters treated for SARS-CoV-2 infection. MK-4482, delivered orally, is now in Phase 2 and 3 human clinical studies. Beverages giant Coca-Cola reported a 19 percent decline in profit for the second quarter from last year as a revenue growth of 5 percent and improved margins were offset by higher income taxes and interest expense. However, adjusted earnings per share and revenues topped analysts' expectations. The company also maintained its adjusted earnings and organic revenue growth outlook for fiscal 2021.
Follow RTT