CureVac Says CV2CoV Showed High Immunogenicity Against Virus Variants In Preclinical Study

Biopharmaceutical company CureVac N.V. (CVAC) announced Thursday that its second generation COVID-19 vaccine candidate, CvnCoV, demonstrated high immunogenicity against virus variants in preclinical study. The first clinical trials for CV2CoV are expected to start in the third quarter of 2021.

CV2CoV is being developed in collaboration between Germany's CureVac and GlaxoSmithKline plc (GSK). This second generation vaccine candidate differs from CureVac's first-generation vaccine candidate, CVnCoV, currently in late-stage clinical testing.

The new CV2CoV vaccine candidate is based on a new mRNA backbone that features targeted optimizations designed to improve intracellular mRNA stability and translation for increased and extended protein expression.

CV2CoV showed high levels of antigen production in rat model. There was also a fast onset of strong neutralizing antibody titers after first vaccination and high cross-neutralizing capacity of induced antibodies against selected COVID-19 variants of concern, including the Denmark variant (B.1.1.298), the UK variant (B.1.1.7) and the South African variant (B.1.351).

CureVac and GlaxoSmithKline aim to jointly develop second-generation vaccine candidates that offer improved immune responses and target emerging variants. Combined with lower doses, these second-generation vaccines could enable also broad protection against selected strains in a multivalent vaccine format.

The COVID-19 collaboration between CureVac and GlaxoSmithKline announced in February 2021 extends the existing strategic mRNA technology partnership both companies entered in July 2020.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
When Can We Expect Starlink to Go Public? This question got an answer from Tesla and SpaceX CEO Elon Musk, who said he will only publicly list SpaceX's satellite internet service Starlink when its revenue is more predictable. Musk was responding to a users tweet, "Any thoughts on Starlink IPO we would love to invest in the future. Any thoughts on first dibs for Tesla retail investors?" John David McAfee, who founded the antivirus software company McAfee Associates, has been found dead in a prison cell in Spain shortly after a Spanish court agreed to extradite him to the US to face tax evasion charges, multiple reports said. He was arrested in Spain in October 2020 after being accused of failing to file tax returns for four years. While reporting financial results for the first quarter of fiscal 2022 on Thursday, drugstore chain Rite Aid Corp. (RAD) initiated its adjusted loss and total revenue guidance for the full-year 2022, below analysts' estimates. For fiscal 2022, the company now projects an adjusted loss in a range...
Follow RTT