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Adagio Says New Data Highlight Potential Of ADG20 For Treatment And Prevention Of Covid-19

Adagio Therapeutics Inc. (ADGI) announced new data highlighting the potential of ADG20 for the treatment and prevention of covid-19.

ADG20, a monoclonal antibody targeting the spike protein of SARS-CoV-2 and related coronaviruses, is being developed for the prevention and treatment of COVID-19, the disease caused by SARS-CoV-2.

According to the company, ADG20 continues to be well tolerated in healthy volunteers with prolonged half-life and serum virus neutralization activity observed out to six months in ongoing phase 1 study.

The company noted that data from quantitative systems pharmacology/whole-body physiologically based pharmacokinetic modeling support evaluation of 300 mg intramuscular dose of ADG20 given as a single intramuscular injection in ongoing phase 2/3 studies.

"The continued strength of the safety and pharmacokinetic data from our Phase 1 study is encouraging and further underscores the potential impact an antibody like ADG20 - which was designed to be potent, broadly neutralizing and delivered as a single IM injection - could have on people with or at risk of COVID-19," said Lynn Connolly, chief medical officer of Adagio.

The company stated that the phase 1 data combined with its dose selection strategy have allowed the company to initiate and advance its pivotal trials of ADG20 in the treatment and prevention of COVID-19.

The company anticipates the data will support an Emergency Use Authorization application in the first quarter of 2022, which could enable the company to bring an important treatment option to patients.

The company said data will be presented during IDWeek 2021 and 19th annual discovery on target conference on September 30, 2021.

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