Aerie Announces Positive Phase 3 Results For Netarsudil Ophthalmic Solution 0.02% Trial In Japan

Aerie Pharmaceuticals Inc. (AERI) said it has successfully completed its first phase 3 clinical trial in Japan which further confirmed that netarsudil ophthalmic solution 0.02% achieves impressive intraocular pressure or IOP-lowering efficacy in a patient population with lower baseline pressures.

In Tuesday pre-market trade, AERI was trading at $14.29 up $1.24 or 9.50%.

The IOP-lowering with netarsudil was consistent with that seen in the previous Phase 2 study conducted in Japan as well as in ROCKET and MERCURY studies conducted in the United States for Rhopressa and Rocklatan, respectively.

Phase 3 clinical trial in Japan evaluated netarsudil ophthalmic solution 0.02% versus ripasudil hydrochloride hydrate ophthalmic solution 0.4% or "ripasudil 0.4%". The results showed that netarsudil 0.02% once daily was superior to ripasudil 0.4% twice daily in lowering intraocular pressure at week four, the primary endpoint for the study.

Both netarsudil 0.02% and ripasudil 0.4% are Rho kinase (ROCK) inhibitors. They are designed to treat open-angle glaucoma and elevated IOP by increasing outflow of aqueous humor through the trabecular outflow pathway, the drainage pathway responsible for maintaining normal IOP in the eye.

The company noted that the findings also suggest that the IOP reduction may predict strong efficacy in normal or low-tension glaucoma patients.These patients suffer damage to the optic nerve in spite of having IOPs in the normal range. Historically it has been challenging to achieve the IOP reductions needed to prevent vision loss in this patient population.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
The Goldman Sachs Group, Inc. (GS) reported that its third quarter net earnings applicable to common shareholders increased 63 percent year-on-year. Net revenues were also significantly higher reflecting significantly higher net revenues in Investment Banking, Global Markets and Consumer & Wealth Management,... Butterball, LLC recalled about 14,107 pounds of ground turkey products for potential contamination with foreign materials, specifically blue plastic material, the U.S. Department of Agriculture's Food Safety and Inspection Service (FSIS) said in a statement. Specialized Bicycle Components, Inc. is recalling about 6,900 units of Tarmac SL7 Bicycles and Framesets for potential risk of fall and injury hazard, a statement by the U.S. Consumer Product Safety Commission (CPSC) showed. The company said the bicycle's fork steerer tube can crack or break after harsh impact such as hitting a deep pothole or other stress event, posing fall and injury hazards.
Follow RTT