logo
  

Clearside Reports Positive Safety Results From OASIS Phase 1/2a Trial Of CLS-AX - Quick Facts

Clearside Biomedical, Inc. (CLSD) reported positive safety results from OASIS, an ongoing phase 1/2a clinical trial of CLS-AX administered by suprachoroidal injection via SCS Microinjector. The company said the data reported includes results from Cohort 2 as well as combined data from Cohorts 1 and 2. The primary endpoints were achieved in Cohort 2, as the 0.1 mg dose of CLS-AX was well tolerated with no serious adverse events. The OASIS Safety Monitoring Committee has approved advancing to Cohort 3 with a dose of 0.5 mg of CLS-AX.

"We believe the absence of any dose limiting toxicities in the first two cohorts of the OASIS trial, combined with our pre-clinical toxicology data, supports our plan to escalate to the higher CLS-AX dose of 0.5 mg in Cohort 3 rather than the previous 0.3 mg dose. We have initiated patient screening for Cohort 3, with target completion of this cohort planned for mid-year 2022," said Thomas Ciulla, Chief Medical Officer.

OASIS is evaluating CLS-AX for the treatment of neovascular age-related macular degeneration.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Teva Pharmaceuticals USA, Inc. has recalled one lot of platelet-reducing drug Anagrelide in the form of capsules due to dissolution test failure detected during routine stability testing, the U.S. Food and Drug Administration, or FDA, said in a statement. The U.S. Food and Drug Administration said it has taken steps to make available millions of cans of additional infant and specialty formula to U.S. consumers in the coming months. Under the agency's recent increased flexibilities, British nutrition products maker Kendal Nutricare will send about 2 million cans of infant formula under the Kendamil brand initially to U.S. beginning in June. Video streaming giant Netflix Inc. announced the availability of a variety of mobile games. Players can download the games directly from the Netflix mobile app. The new games include Dragon Up (East Side Games), Moonlighter (11 Bit Studios), Townsmen - A Kingdom Rebuilt (HandyGames), and Exploding Kittens - The Game (Exploding Kittens Digital).
Follow RTT