logo
  

OPKO Announces Positive Results From Phase 2 Trial Of Rayaldee On Symptomatic COVID-19 Treatment

OPKO Health Inc. (OPK) announced preliminary positive results from its Phase 2 trial with Rayaldee to treat mild-to-moderate COVID-19. The preliminary data indicated that vitamin D repletion therapy can mitigate the severity of upper respiratory tract infections and accelerate recovery from COVID-19.

Rayaldee, after oral administration, gradually releases calcifediol, the natural storage form of vitamin D3, to safely and reliably raise a patient's serum total 25-hydroxyvitamin D (25D) well above current targets of 20 or 30 ng/mL.

Rayaldee is approved in the U.S. and many European countries for treating secondary hyperparathyroidism in non-dialysis chronic kidney disease (CKD) patients by raising 25-hydroxyvitamin D to levels as high as 100 ng/mL.

One primary efficacy endpoint was reaching the targeted serum 25D level. By Day 7, mean serum 25D levels increased with Rayaldee treatment to 82 ng/mL and remained elevated for the duration of the trial, with 88% of subjects attaining the targeted level. In contrast, mean 25D declined slightly with placebo treatment.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
The Federal Trade Commission or FTC, has sued Walmart for allowing its money transfer services to be used by fraudsters, who fleeced consumers out of hundreds of millions of dollars. The retail giant is alleged to have looked the other way to pocket millions in fees while scammers took advantage of its failure to properly secure the money transfer services offered at Walmart stores. Home improvement retailer Bed Bath & Beyond, Inc. (BBBY) reported on Wednesday a net loss for first quarter that sharply widened from last year, hurt by hefty transient costs related to inventory markdown reserves and port-related supply chain fees. Both adjusted loss per share and net sales missed analysts' expectations. Tesla Inc. laid off about 200 employees in its Autopilot unit as the luxury electric car maker closed down its office in San Mateo, California as part of cost cutting efforts, reports said. The San Mateo office, where employees worked on improving the driver assistance systems, marketed as Autopilot, had about 350 employees before the cut.
Follow RTT