Ascletis' ASC22 Shows Potential Of Functional Cure Of Chronic Hepatitis B In Phase IIb Trial

Ascletis Pharma Inc. presented Phase IIb clinical trial results of subcutaneous PD-L1 antibody ASC22 for functional cure of chronic hepatitis B at oral session of EASL ILC 2022 on June 25, 2022, Beijing Time.

The Phase IIb clinical trial results further demonstrated the potential of ASC22+nucleos(t)ide analogs treatment as a functional cure for chronic hepatitis B.

The interim report is based on a randomized, single-blind, multi-center Phase IIb clinical trial to assess the efficacy and safety of ASC22 in treatment of chronic hepatitis B or CHB patients.

In 1.0 mg/kg ASC22 cohort, 75 CHB patients were randomized to be treated with 1.0 mg/kg ASC22 (n=60) or placebo (PBO, n=15) once every 2 weeks plus nucleos(t)ide analogs (NAs) for 24-week and then followed for another 24 weeks.

According to the Phase IIb clinical study results, 42.9% patients with baseline HBsAg =100 IU/mL (n=7) obtained sustained HBsAg loss. ALT flares were observed on 21% patients in ASC22 group (n=48) while none in PBO group.

Patients with ALT flares had more HBsAg reduction. Among the three patients with sustained HBsAg loss, two experienced ALT flares.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Seffner, Florida -based Canyon Furniture Co. is recalling ladders sold with bunk bed and hutch sets citing entrapment and strangulation risks, the U.S. Consumer Product Safety Commission said. The about 2,100 units of Canyon Lake and Cottage Colors Bunk Bed and Hutch Sets were sold exclusively at Rooms To Go. Lyft announced the expansion to its partnership with Indeed in Jobs Access program. The ride-hailing company will be providing transportation access for Indeed's Ready to Work program. Indeed's Ready to Work program is a series of free virtual and in-person events for job seekers in several cities across the U.S. from September 15 to October 8, 2022. Pool and Spa drain covers imported to the United States by various companies have been recalled due to violation of the Virginia Graeme Baker Pool and Spa Safety Act, the U.S. Consumer Product Safety Commission announced. The various recalls include pool and spa drain covers manufactured in China and sold exclusively at Amazon.com for different prices ranging from $10 to $12.
Follow RTT