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OBI Pharma Discontinues Phase 1/2 Study Of Antibody-OBI 888

OBI Pharma, a Taiwan biopharma company, said it has discontinued the phase 1/2 Study for OBI 888, a Globo H antibody.

According to the company, preliminary data from phase 1/2 study demonstrated that OBI 888 is a safe and well tolerated product and showed some trends of efficacy. However, due to the higher antibody amount required for the OBI-888 treatment compared to the ADC, OBI-999, and an unexpected low drug yield at the large manufacturing scale, OBI-888 no longer fulfills goal of developing cost-effective therapies for cancer patients.

The company said it will focus on novel cancer pipeline under phase 3 (Adagloxad Simolenin-vaccine) and phase 2 (OBI 999-ADC, OBI 833-vaccine and OBI 3424-small molecule) clinical development.

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