Regeneron's REGN5678 Shows Encouraging Anti-tumor Activity When Combined With Libtayo

Regeneron Pharmaceuticals, Inc. (REGN) on Wednesday reported encouraging initial data from Phase 1/2 study of REGN5678 in combinations with the company's Libtayo in advanced metastatic castration-resistant prostate cancer (mCRPC).

The Phase 1/2 study is currently enrolling patients with advanced mCRPC whose tumors have previously progressed on multiple anti-androgen therapies, with a majority also having received prior chemotherapy.

In the Phase 1 dose-escalation portion of the Phase 1/2 study, patients with advanced mCRPC were initiated with weekly doses of REGN5678, for three weeks, which then continued in combination with standard dose of anti-PD-1 agent Libtayo.

Preliminary data from the dose-escalation portion of the trial, across 8 dose level cohorts and a total of 33 patients, showed dose-dependent anti-tumor activity per centrally collected prostate-specific antigen (PSA) values.

PSA is a protein produced by the prostate gland and is commonly used as a biomarker to diagnose and follow prostate cancer.

The lack of anti-tumor activity among these patients was consistent with the approximate 6% response rate reported in other trials with anti-PD1 monotherapy, the company said.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Seffner, Florida -based Canyon Furniture Co. is recalling ladders sold with bunk bed and hutch sets citing entrapment and strangulation risks, the U.S. Consumer Product Safety Commission said. The about 2,100 units of Canyon Lake and Cottage Colors Bunk Bed and Hutch Sets were sold exclusively at Rooms To Go. Lyft announced the expansion to its partnership with Indeed in Jobs Access program. The ride-hailing company will be providing transportation access for Indeed's Ready to Work program. Indeed's Ready to Work program is a series of free virtual and in-person events for job seekers in several cities across the U.S. from September 15 to October 8, 2022. Pool and Spa drain covers imported to the United States by various companies have been recalled due to violation of the Virginia Graeme Baker Pool and Spa Safety Act, the U.S. Consumer Product Safety Commission announced. The various recalls include pool and spa drain covers manufactured in China and sold exclusively at Amazon.com for different prices ranging from $10 to $12.
Follow RTT