Vera Therapeutics (VERA) announced that the primary endpoint was met in the ORIGIN
Phase 3 trial of atacicept for the treatment of immunoglobulin A nephropathy in adults. Participants treated with atacicept achieved a 46% reduction from baseline in
proteinuria, with a statistically significant and clinically meaningful 42% reduction in urine protein-to-creatinine ratio compared to placebo at week 36. Vera plans to share the results with the FDA in the coming weeks.
ORIGIN 3 is an ongoing global, multicenter, randomized, double-blind, placebo-controlled Phase 3 trial of 431 adults with IgA nephropathy. The trial continues in a placebo-controlled blinded manner to evaluate the change in kidney function over two years and is expected to complete in 2027.
Shares of Vera Therapeutics are up 71% in pre-market trade on Monday.
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