Medivation, Inc. (MDVN) on Monday announced top-line results of a Phase 2 study showing that its investigational drug Dimebon significantly improved cognitive function in patients with mild-to-moderate Huntington's disease.
The primary endpoint of the trial was safety and tolerability. The secondary endpoint was efficacy, as measured by the MMSE, the UHDRS and the Alzheimer's Disease Assessment Scale-cognitive subscale.
Results showed that Dimebon was very well tolerated in this trial. The overall incidence of adverse events was lower in the Dimebon group than in the placebo group, an unusual finding in a clinical study of any drug.
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