COVID-19: Drugs in Development


The COVID-19 outbreak, which started in December 2019 in Wuhan City, China, was declared a "Public Health Emergency of International Concern" by the WHO on January 30, 2020. The outbreak was characterized as a pandemic on March 11, 2020.

Currently, there are no drugs to treat COVID-19, caused by the novel coronavirus SARS-CoV-2.

Listed below are companies that are in the race to find a treatment or vaccine for the novel coronavirus.

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Company Name
Current Stage
Next Milestone
Last Updated
Jiangsu Recbio Technology Co., Ltd.
Emergency use authorization for ReCOV was received in Mongolia- reported on Mar 21, 2023.

Results from the Phase 2 study showed that neutralizing antibody titer levels against Omicron BF.7 and BA.2.75 induced by sequential vaccination of ReCOV were significantly better than those of the mRNA vaccine group- reported on Dec.25 2022.
Direct Biologics
Favorable safety, dosing and efficacy results from the Phase 2 study of ExoFlo in hospitalized COVID-19 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) were reported on Mar.14, 2023.

The FDA granted Regenerative Medicine Advanced Therapy (RMAT) designation for ExoFlo for the treatment of Acute Respiratory Distress Syndrome (ARDS) associated with COVID-19- reported on Apr. 12, 2022.
Dosing of patients in the Phase 1 study of DYAI-100 COVID-19 booster vaccine candidate was completed and no serious adverse events have been reported as on March 7, 2023.
Initial safety and antibody response update expected in Q2, 2023.
FDA declined the request for Emergency Use Authorization (EUA) for sabizabulin to treat hospitalized COVID-19 patients who are at high risk for Acute Respiratory Distress Syndrome (ARDS).- reported on Mar.2, 2023.
Valneva SE
Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued positive opinion for the use of VLA2001 in adults 18 to 50 years of age as a booster dose- reported on Feb.23, 2023.

Data showed that additional booster dose of VLA2001 in participants who were previously vaccinated with 2 or 3 doses of mRNA COVID-19 vaccine elicited only a marginally increased neutralizing antibody response- reported on Dec.30, 2022.
Shionogi & Co., Ltd.
ensitrelvir (S-217622)
Phase 3 study of Ensitrelvir conducted in Japan met primary endpoint- reported on Feb.21, 2022.

Ensitrelvir received emergency regulatory approval from the Ministry of Health, Labour and Welfare (MHLW) in Japan for the treatment of SARS-CoV-2 Infection- Reported on Nov.22, 2022.
Kinarus Therapeutics Holding AG
KIN001- to treat Covid-19
No safety concerns associated with KIN001 were identified in patients who have completed the 2-week treatment regimen in Phase 2 study- reported on Feb.21, 2023.

KIN001 showed strong antiviral activity against the SARS-CoV-2 Omicron subvariants BA.2 and BA.5 in pre clinical studies- reported on Dec.6, 2022.

The search for treatments to battle the novel coronavirus (COVID-19) is an ongoing process. With the world on alert, pharmaceutical companies around the globe are rapidly developing drugs to help combat this deadly virus. This calendar tracks various Coronavirus Drug companies and COVID-19 Vaccine progress, and lists the companies currently working on drugs against COVID-19.

Understanding the Vaccine Development Process

Vaccines for Covid-19 are produced in a well-defined process. Steps typically include preclinical research, which includes basic studies to determine the safety and efficacy of a potential vaccine; phases 1, 2 and 3 of clinical trials, that involve increasing numbers of volunteers until ultimately large scale trials can confirm safety and efficacy; and finally regulatory review, manufacturing, and distribution. Each step requires specific resources, skills, infrastructure and time before the vaccine is made available to the public.

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Editors Pick
The US Food and Drug Administration has cleared cultivated chicken developed by GOOD Meat Inc., the cultivated meat division of alternative foods startup Eat Just Inc. This is FDA's second pre-market consultation for a human food made from cultured animal cells after UPSIDE Foods. GOOD Meat is now required to meet Federal requirements including approvals from the US Department of Agriculture. A group of 23 U.S. states attorneys general have asked South Korean car manufacturers Hyundai Motor and Kia Corp. to take action more quickly to solve problems with millions of U.S. vehicles facing theft. The issue is related to the companies' failure to equip vehicles with anti-theft immobilizers, which has been a standard equipment on vehicles sold by other major manufacture El Monte, California-based Mutual Trading Co., Inc. is recalling certain Kagome Sauces citing undeclared soy, a known allergen, the U.S. Food and Drug Administration said. The recall involves 60 fl oz of Kagome Worcester Sauce, 10 fl oz of Kagome Chuno sauce, and 8g of Kagome Take out Tonkatsu Sauce.