COVID-19: Drugs in Development


The COVID-19 outbreak, which started in December 2019 in Wuhan City, China, was declared a "Public Health Emergency of International Concern" by the WHO on January 30, 2020. The outbreak was characterized as a pandemic on March 11, 2020.

Currently, there are no drugs to treat COVID-19, caused by the novel coronavirus SARS-CoV-2.

Listed below are companies that are in the race to find a treatment or vaccine for the novel coronavirus.

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Company Name
Current Stage
Next Milestone
Last Updated
Arcturus Therapeutics Ltd.
ARCT-154 and ARCT-165 Covid-19 Vaccines
On Aug. 3, 20121, ARCT-154 and ARCT-165, STARR mRNA Vaccines targeting SARS-CoV-2 Variants of concern, given clearance to move into Phase 1/2 study in Singapore
Shenzhen Kangtai Biological Products Co., Ltd. (300601.SZ)
-- Approved in China for emergency use on May 14, 2021
-- Phase 3 trial initiated in Malaysia on Jun.21, 2021
-- On Aug.2, 2021, received approval in the Philippines to launch phase 3 trial
-- Seeking to launch clinical trials in more countries and regions in South America, Europe, etc
-- Launch trials in Ukraine in August
Direct Biologics
Two clinical trials evaluating ExoFlo for the treatment of COVID-19-related acute respiratory distress syndrome (ARDS) in inpatient and ICU setting have been completed
-- Commence Phase 1/2 trial for mild-to-moderate COVID-19, called EMOTE COVID-19, later in 2021
-- Start phase 1/2 trial for for Post-Acute COVID-19 Syndrome, dubbed EIPACS, later in 2021
Therapeutic Solutions International, Inc.
Phase I/IIa trial

-- Data reported on May 21, 2021, showed that JadiCell substantially improved survival in end-stage patients with COVID-19 associated Acute Respiratory Distress Syndrome
--On Jul.27, 2021, preclinical data was reported, suggesting efficacy of JadiCell in animal model resembling COVID-19 Delta Variant associated lung pathology
Conducting Phase III pivotal trial
BetterLife Pharma Inc.
AP-003 given clearance in Chile to enter into phase I/II trial (IN2COVID )
IN2COVID trial set to start in early August
Revive Therapeutics Ltd.
Phase 3 trial in mild to moderate COVID-19.
-- The next independent Data and Safety Monitoring Board review of the study in Q3, 2021
-- Enrollment in phase 3 trial to be completed in Q3, 2021
Todos Medical, Ltd.
Phase 2/3 trials of Tollovir for the treatment of non-hospitalized and hospitalized COVID-19 patients to begin in India
-- Enrollment for both trials to begin in Q3, 2021, with data expected in 4Q, 2021
-- Pivotal trial to begin in 4Q, 2021
NLC Pharma
Augmenta Bioworks
In vivo preclinical study

--Data released on Jul.29, 2021, showed AUG-3387 can neutralize SARS-CoV-2 Delta Variant in infective assays
-- In vivo preclinical efficacy studies to be completed in the coming weeks

-- Toxicology studies to start by the end of 2021
TFF Pharmaceuticals Inc. (TFFP)

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