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COVID-19: Drugs in Development

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The COVID-19 outbreak, which started in December 2019 in Wuhan City, China, was declared a "Public Health Emergency of International Concern" by the WHO on January 30, 2020. The outbreak was characterized as a pandemic on March 11, 2020.

Currently, there are no drugs to treat COVID-19, caused by the novel coronavirus SARS-CoV-2.

Listed below are companies that are in the race to find a treatment or vaccine for the novel coronavirus.

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Company Name
Drug
Current Stage
Next Milestone
Collaboration
Last Updated
Virios Therapeutics Inc
(VIRI)
IMC-2
Study evaluating IMC-2 in Long-COVID treatment was initiated-reported on Aug.15, 2022.
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-
08/16/2022
Ascletis Pharma Inc.
ASC10
China National Medical Products Administration accepted the Investigational New Drug (IND) application of ASC10 for the treatment of Covid-19- reported on Aug 03, 2022.

The FDA gave clearance to conduct Phase Ib study of ASC10 in mild-to-moderate COVID-19 patients-reported on Aug 03, 2022.

IND application of ASC10 for the treatment of Covid-19 has been filed with the FDA- reported on Jul 05, 2022.
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-
08/05/2022
Sorrento Therapeutics, Inc.
(SRNE)
STI-1558 to treat Covid-19
Multiple ascending dose (MAD) Phase 1 study of STI-1558 was initiated following successful completion of single ascending dose (SAD) study- reported on Aug 03, 2022

The FDA has cleared the Investigational New Drug application for a Phase 1 pharmacokinetic study of STI-1558 in patients with impaired renal and hepatic function- reported on July 19, 2022.
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08/04/2022
SyneuRx International
Pentarlandir
Results from Phase 2 study showed that Pentarlandir can reduce the inflammation caused by COVID-19 and improve overall health- reported on July 31, 2022.

On Nov.19, 2021, the company announced that pentarlandir has shown significant anti-viral properties with minimal observed side effects in the phase II study.
Phase 3 study to be launched in the coming months.
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08/03/2022
AIM ImmunoTech Inc.
(AIM)
Ampligen
Preliminary data from the pilot study showed that patients with long COVID had statistically significant improvements in chronic fatigue after treatment with Ampligen- reported on July 28, 2022.

After at least 12 weeks of Ampligen treatment, four patients with new onset Myalgic encephalomyelitis/chronic fatigue syndrome, following acute COVID-19, experienced a reduction in fatigue- reported on May 18, 2022.
An IND application to be submitted with the FDA for a Phase 2 study of Ampligen for the treatment of Post-COVID conditions
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07/29/2022
InflaRx N.V.
(IFRX)
IFX-1 (vilobelimab)
Topline results from the Phase III part of Phase II/III PANAMO study of Vilobelimab in mechanically ventilated COVID-19 patients showed a relative reduction in 28-day all-cause mortality of 23.9% compared to placebo, but did not show statistical significance on the pre-specified primary endpoint- reported on March 31, 2022.
Emergency Use Authorization (EUA) application for Vilobelimab to be submitted in Q3 2022
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07/27/2022
Brii Biosciences Limited
BRII-196 and BRII-198
New live virus data showed that the BRII-196 and BRII-198 (amubarvimab/ romlusevimab) combination, retains neutralizing activity against the Omicron BA.4/5 and BA.2.12.1 SARS-CoV-2 subvariants- reported on Jul 26, 2022.
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07/27/2022
Vaxart, Inc.
(VXRT)
Oral tablet COVID-19 vaccine
Additional data from the Phase 1 study showed that tablet COVID-19 vaccine induced long-lasting mucosal IgA antibodies against SARS-CoV-2, and all tested coronaviruses- reported on July 20, 2022.

Phase 2 study of Oral Tablet COVID-19 Vaccine was initiated on October 26, 2021.
Data from the dose selection portion of the two part dose-ranging and preliminary efficacy Phase II trials of oral tablet COVID-19 vaccine candidate are expected in the third quarter of 2022.
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07/21/2022

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Editors Pick
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