Researchers have discovered a gene, Katnal1, integral to the manufacture of healthy sperm. The discovery opens the door to the possibility for a male contraceptive which would interrupt the functioning of that gene, say scientists in a recent report published in PLos Genetics.
Katnal1 plays a crucial role in cell shape, division and mobility, and, in the testes, determines the formation of the sperm head and tail.
"If we can find a way to target this gene in the testes, we could potentially develop a non-hormonal contraceptive," said Dr. Lee Smith in a statement.
"The important thing is that the effects of such a drug would be reversible because Katnal1 only affects sperm cells in the later stages of development, so it would not hinder the early stages of sperm production and the overall ability to produce sperm," he added.
The study may also shed light on why some men are sub-fertile or have improperly functioning sperm.
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