Synthetic lethality provides a new opportunity in oncology drug development. First described by Calvin Bridges in 1922, synthetic lethality arises when deficiencies in a pair of genes occur simultaneously to result in cell death, but if that deficiency exists in only one gene, the cell will survive.
The company we are profiling today is a clinical-stage precision oncology company focused on synthetic lethality - Repare Therapeutics Inc. (RPTX).
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