Chronic rhinosinusitis (CRS) is an inflammatory condition that leads to prolonged periods of nasal congestion, facial discomfort, pressure, and nasal discharge, often lasting for months or even years. In the United States, roughly 8 million people are treated for CRS annually. It can manifest as either chronic sinusitis without nasal polyps, chronic sinusitis with nasal polyps, or allergic fungal rhinosinusitis.
Dupixent, Xolair, Xhance and Nucala are some of the FDA-approved drugs for chronic sinusitis with nasal polyps. Xhance is also approved for the treatment of chronic rhinosinusitis without nasal polyps, and it is the first and only medication indicated for this condition.
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