Stiff person syndrome (SPS) is a rare autoimmune neurological disorder that causes muscle stiffness in the torso, arms, and legs, which can make movement difficult. Around 80% of patients experience significant loss of mobility, often requiring walking aids or a wheelchair, and the condition carries a risk of permanent disability and increased mortality.
Currently, there are no therapies specifically approved by the FDA for SPS, and so treatment focuses on managing symptoms and improving quality of life. This typically involves a combination of medications to reduce stiffness and spasms, immunotherapies to address the underlying autoimmune process, and supportive care such as physical and occupational therapy to maintain function and independence.
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