Array BioPharma Inc. (ARRY) said that the Gynecologic Oncology Group presented results of a Phase 2 trial with selumetinib, a small-molecule MEK inhibitor, in women with recurrent low-grade serous ovarian or peritoneal cancer. Selumetinib was invented by Array BioPharma and licensed to AstraZeneca (AZN,AZN.L).
The Gynecological Oncology Group revealed a disease control rate, defined as either complete or partial response or progression-free survival or progression-free survival of greater than 6 months, of 81% of patients. Eight patients had complete or partial responses, and 34 had progression-free survival of greater than 6 months. The median survival rate without cancer progression was 11 months.
In the reported trial, 52 women each received 100-mg doses of selumetinib orally twice daily in four-week cycles until disease progression or toxicity. Prior to the trial, 58% of the patients in the trial had received three or more rounds of chemotherapy.
Array anticipates top-line results for the Phase 2 trial with selumetinib in combination with dacarbazine versus dacarbazine alone as first-line treatment in patients with BRAF-mutant melanoma to be reported in 2012. In addition, Array expects that further data and analyses will be presented in the second quarter of 2012 for the randomized Phase 2 trial conducted by AstraZeneca comparing selumetinib in combination with docetaxel versus docetaxel alone in the second-line treatment of patients prospectively selected with KRAS-mutant, locally advanced or metastatic, non-small cell lung cancer.
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June 12, 2026 17:14 ET Major central bank action was the focus this week in economic news. The European Central Bank became the first major central bank to move in response to the rising inflationary pressures in the backdrop of the conflict in the Middle East. In North America, the U.S. inflation and trade data as well as Canada’s central bank decision gained attention. The Chinese trade data was the main news in Asia.