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FDA Calendar

PDUFA dates and FDA Panel Review dates are very important catalysts because they are ‘make or break events’ for biotech stocks.

The goal date set by the FDA for announcing its decision on a company’s New Drug Application/ Biologics License Application/sBLA/sNDA after reviewing the applications is known as the PDUFA date.

Usually, the stocks experience a run-up going into the scheduled FDA Approval decision/FDA Panel review events. So, having prior knowledge of the key dates goes a long way toward maximizing profit or minimizing loss while investing in the volatile biotech stocks.

Listed below are large cap, mid cap and small cap stocks with pending regulatory catalysts.

Get in-depth analysis and insight on investing in the high-stakes Biotech and Pharma sectors. Check out RTT Biotech Investor and our Biotech Home Page.

Company Name
Drug
Event
Outcome
Details
Merck & Co Inc.
(MRK)
Winrevair (sBLA)
10/25/2025
FDA decision to update the label of Winrevair update to labeling for WINREVAIR to include the results of the Phase 3 ZENITH trial
FDA expanded the indication of WINREVAIR to include components of the clinical worsening events: hospitalization for PAH, lung transplantation and death, based on phase 3 ZENITH study, on Oct.27, 2025-
Bayer AG
(BYR.L, BAYRY.PK, BAYZF.PK, BAY.MI, BAYN.DE)
Elinzanetant (NDA)
10/26/2025
FDA decision on Elinzanetant for moderate-to-severe vasomotor symptoms (VMS) associated with menopause
FDA approved Elinzanetant for moderate-to-severe vasomotor symptoms (VMS) associated with menopause, under the brand name Lynkuet, on Oct.24, 2025-
Arrowhead Pharmaceuticals, Inc.
(ARWR)
Plozasiran (NDA)
11/18/2025
FDA decision on Plozasiran for the treatment of familial chylomicronemia syndrome
Pending-
Bayer AG
(BYR.L, BAYRY.PK, BAYZF.PK, BAY.MI, BAYN.DE)
Sevabertinib (NDA)
11/28/2025
FDA decision on Sevabertinib for the treatment of patients with non-small cell lung cancer harboring HER2 activating mutations
FDA Approves HYRNUO (sevabertinib) for HER2-Mutated Locally Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer on Nov 20, 2025-
Otsuka Holdings Co., Ltd.
( OTSKF, 4578.T)
Sibeprenlimab (BLA)
11/28/2025
FDA decision on Sibeprenlimab in the treatment of Immunoglobulin A Nephropathy (IgAN) in adults
Pending-
Kura Oncology Inc.
(KURA)
ziftomenib (NDA)
11/30/2025
FDA decision on ziftomenib for treatment for adult patients with relapsed or refractory acute myeloid leukemia with a nucleophosmin 1 mutation
FDA approved KOMZIFTI (ziftomenib), the first and only once-daily targeted therapy for adults with relapsed or refractory NPM1-Mutated Acute Myeloid Leukaemia on Nov.13, 2025-
Ascendis Pharma A/S
(ASND)
TransCon CNP (NDA)
11/30/2025
FDA decision on TransCon CNP (navepegritide) for the treatment of children with achondroplasia
On Nov. 25, 2025, the FDA informed the company that it is postponing the decision date on TransCon CNP by three months-
Bristol Myers Squibb Co.
(BMY)
Breyanzi (sBLA)
12/05/2025
FDA decision to expand the use of Breyanzi as a potential treatment for adult patients with relapsed or refractory marginal zone lymphoma
FDA approved Breyanzi for the treatment of adult patients with relapsed or refractory marginal zone lymphoma who have received at least two prior lines of systemic therapy on Dec.4, 2025 -
AxoGen, Inc.
(AXGN)
Avance Nerve Graft (BLA)
12/05/2025
FDA decision on Avance Nerve Graft for surgical repair of severed peripheral nerves
FDA approved AVANCE Nerve Graft on December 3, 2025-
Agios Pharmaceuticals, Inc.
(AGIO)
Pyrukynd (sNDA)
12/07/2025
FDA decision on Pyrukynd for the treatment of adult patients with non-transfusion-dependent and transfusion-dependent alpha- or beta-thalassemia
Pending-

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