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COVID-19: Drugs in Development

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The COVID-19 outbreak, which started in December 2019 in Wuhan City, China, was declared a "Public Health Emergency of International Concern" by the WHO on January 30, 2020. The outbreak was characterized as a pandemic on March 11, 2020.

Currently, there are no drugs to treat COVID-19, caused by the novel coronavirus SARS-CoV-2.

Listed below are companies that are in the race to find a treatment or vaccine for the novel coronavirus.

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Company Name
Drug
Current Stage
Next Milestone
Collaboration
Last Updated
Virios Therapeutics Inc
(VIRI)
IMC-2
Study evaluating IMC-2 in Long-COVID treatment was initiated-reported on Aug.15, 2022.
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-
08/16/2022
Ascletis Pharma Inc.
ASC10
China National Medical Products Administration accepted the Investigational New Drug (IND) application of ASC10 for the treatment of Covid-19- reported on Aug 03, 2022.

The FDA gave clearance to conduct Phase Ib study of ASC10 in mild-to-moderate COVID-19 patients-reported on Aug 03, 2022.

IND application of ASC10 for the treatment of Covid-19 has been filed with the FDA- reported on Jul 05, 2022.
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-
08/05/2022
Sorrento Therapeutics, Inc.
(SRNE)
STI-1558 to treat Covid-19
Multiple ascending dose (MAD) Phase 1 study of STI-1558 was initiated following successful completion of single ascending dose (SAD) study- reported on Aug 03, 2022

The FDA has cleared the Investigational New Drug application for a Phase 1 pharmacokinetic study of STI-1558 in patients with impaired renal and hepatic function- reported on July 19, 2022.
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08/04/2022
SyneuRx International
Pentarlandir
Results from Phase 2 study showed that Pentarlandir can reduce the inflammation caused by COVID-19 and improve overall health- reported on July 31, 2022.

On Nov.19, 2021, the company announced that pentarlandir has shown significant anti-viral properties with minimal observed side effects in the phase II study.
Phase 3 study to be launched in the coming months.
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08/03/2022
AIM ImmunoTech Inc.
(AIM)
Ampligen
Preliminary data from the pilot study showed that patients with long COVID had statistically significant improvements in chronic fatigue after treatment with Ampligen- reported on July 28, 2022.

After at least 12 weeks of Ampligen treatment, four patients with new onset Myalgic encephalomyelitis/chronic fatigue syndrome, following acute COVID-19, experienced a reduction in fatigue- reported on May 18, 2022.
An IND application to be submitted with the FDA for a Phase 2 study of Ampligen for the treatment of Post-COVID conditions
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07/29/2022
InflaRx N.V.
(IFRX)
IFX-1 (vilobelimab)
Topline results from the Phase III part of Phase II/III PANAMO study of Vilobelimab in mechanically ventilated COVID-19 patients showed a relative reduction in 28-day all-cause mortality of 23.9% compared to placebo, but did not show statistical significance on the pre-specified primary endpoint- reported on March 31, 2022.
Emergency Use Authorization (EUA) application for Vilobelimab to be submitted in Q3 2022
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07/27/2022
Brii Biosciences Limited
BRII-196 and BRII-198
New live virus data showed that the BRII-196 and BRII-198 (amubarvimab/ romlusevimab) combination, retains neutralizing activity against the Omicron BA.4/5 and BA.2.12.1 SARS-CoV-2 subvariants- reported on Jul 26, 2022.
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07/27/2022
Vaxart, Inc.
(VXRT)
Oral tablet COVID-19 vaccine
Additional data from the Phase 1 study showed that tablet COVID-19 vaccine induced long-lasting mucosal IgA antibodies against SARS-CoV-2, and all tested coronaviruses- reported on July 20, 2022.

Phase 2 study of Oral Tablet COVID-19 Vaccine was initiated on October 26, 2021.
Data from the dose selection portion of the two part dose-ranging and preliminary efficacy Phase II trials of oral tablet COVID-19 vaccine candidate are expected in the third quarter of 2022.
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07/21/2022

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Editors Pick
Delta Air Lines is set to resume flights on its routes between the U.S. and Japan from October 30, 2002 in anticipation of easing of COVID-19-related travel restrictions, which were put in place two years ago. The airline joins American Airlines and United Airlines, who have reportedly announced the resumption of flights to Japan. Tech major Apple Inc. has asked corporate employees to return to offices at least three days a week by September 5, Bloomberg reported. The latest deadline was issued following several delays to its previous deadlines amid a resurgence in COVID-19 cases. As per the report, the company will require employees to work from offices on Tuesdays, Thursdays and a regular third day to be determined by... Retail giant Walmart reported Tuesday a net profit for the second quarter that grew 20.4 percent from last year, reflecting lower operating expenses and partially inflation driven revenue growth. The results were also driven by the rebound in international markets. Quarterly revenues topped analysts' expectations. The retailer also raised its adjusted earnings guidance for the full-year 2023.