Sucampo Pharmaceuticals, Inc. (SCMP) announced the presentation of preclinical data at Digestive Disease Week 2012, in San Diego that shows the protective effect of cobiprostone, also known as SPI-8811, against epithelial barrier dysfunction in models of non-steroidal anti-inflammatory drug, or NSAID,-induced gastric mucosal injury.
In the study presented, treatment with the NSAID indomethacin resulted in increased permeability due to dysregulation of occludin co-localization. The results of this in vitro study show that cobiprostone, via ClC-2 activation, can counter act such adverse effects of NSAID on tight junction proteins. Cobiprostone was also shown to prevent indomethacin-induced cell death.
"NSAIDs are commonly prescribed drugs for pain, fever and inflammation, but are not ideal for long-term use because of the risk of ulcer formation," said Anthony Blikslager, NC State University, College of Veterinary Medicine. "In this study, we demonstrated that cobiprostone exerts a protective effect against epithelial barrier dysfunction in the presence of an NSAID in human gastric epithelial cells. Based on these data, we believe that cobiprostone could serve as a treatment option in patients taking NSAIDs."
For comments and feedback contact: editorial@rttnews.com
Business News
June 12, 2026 17:14 ET Major central bank action was the focus this week in economic news. The European Central Bank became the first major central bank to move in response to the rising inflationary pressures in the backdrop of the conflict in the Middle East. In North America, the U.S. inflation and trade data as well as Canada’s central bank decision gained attention. The Chinese trade data was the main news in Asia.