Quick Facts
FONT-SIZE Plus   Neg
Share SHARE

Amgen's AMG 145 Lowers Bad Cholesterol Levels

RELATED NEWS
Trade AMGN now with 

Amgen Inc. (AMGN: Quote) Monday said its experimental drug AMG 145 in combination with statin therapy reduced bad cholesterol levels in patients.

AMG 145 is an investigational antibody directed against PCSK9, a protein that reduces the liver's ability to remove low density lipoprotein cholesterol (LDL-C) or bad cholesterol from the blood.

Amgen in a statement said AMG 145 in combination with statin therapy, with or without ezetimibe, resulted in a reduction in LDL-C by up to 56 percent in patients with heterozygous familial hypercholesterolemia (HeFH) in the Phase 2 Rutherford study.

HeFH, one of the most common genetic disorder, elevates the cholesterol and LDL-C levels and leads to cardiovascular diseases and death.

The company said treatment with AMG 145 every four weeks resulted in a significant LDL-C decrease versus placebo in HeFH patients on lipid-lowering therapy.

At week 12, LDL-C reduction was 43 percent and 55 percent with AMG 145 350 mg and 420 mg, respectively, compared to a 1 percent increase with placebo arm.

"Despite existing therapies and maintaining a healthy lifestyle, patients with heterozygous familial hypercholesterolemia are prematurely at risk for serious cardiovascular disease due to the difficulty in reducing their LDL-C levels," said Frederick Raal, Carbohydrate & Lipid Metabolism Research Unit, Division of Endocrinology & Metabolism, Department of Medicine, University of the Witwatersrand, Johannesburg.

Register
To receive FREE breaking news email alerts for Amgen Inc. and others in your portfolio

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Editors Pick
Nike Inc., the world's largest athletic shoes and apparel maker, said Thursday after the markets closed that its second quarter profit rose 23% from last year, helped by higher revenue and improved gross margin. The company's quarterly earnings per share also came in above analysts' expectations as did its quarterly revenue. Citing extreme fluctuation of the ruble, Apple Inc. (AAPL) has reportedly discontinued its online sales of products in Russia. Despite efforts of the Russian central bank, the ruble has been spiraling downward, with oil prices plunging to historic levels. The ruble shed around 19 percent on Wednesday.... General Motors said it has halted the delivery of cars to dealerships in Russia as it strives to overcome the business risks stemming from the collapse of the ruble.
comments powered by Disqus
FREE Newsletters, Analysis & Alerts

 

Stay informed with our FREE daily Newsletters and real-time breaking News Alerts. Sign up to receive the latest information on business news, health, technology, biotech, market analysis, currency trading and more.