logo
Share SHARE
FONT-SIZE Plus   Neg

Amgen's AMG 145 Lowers Bad Cholesterol Levels

Amgen Inc. (AMGN) Monday said its experimental drug AMG 145 in combination with statin therapy reduced bad cholesterol levels in patients.

AMG 145 is an investigational antibody directed against PCSK9, a protein that reduces the liver's ability to remove low density lipoprotein cholesterol (LDL-C) or bad cholesterol from the blood.

Amgen in a statement said AMG 145 in combination with statin therapy, with or without ezetimibe, resulted in a reduction in LDL-C by up to 56 percent in patients with heterozygous familial hypercholesterolemia (HeFH) in the Phase 2 Rutherford study.

HeFH, one of the most common genetic disorder, elevates the cholesterol and LDL-C levels and leads to cardiovascular diseases and death.

The company said treatment with AMG 145 every four weeks resulted in a significant LDL-C decrease versus placebo in HeFH patients on lipid-lowering therapy.

At week 12, LDL-C reduction was 43 percent and 55 percent with AMG 145 350 mg and 420 mg, respectively, compared to a 1 percent increase with placebo arm.

"Despite existing therapies and maintaining a healthy lifestyle, patients with heterozygous familial hypercholesterolemia are prematurely at risk for serious cardiovascular disease due to the difficulty in reducing their LDL-C levels," said Frederick Raal, Carbohydrate & Lipid Metabolism Research Unit, Division of Endocrinology & Metabolism, Department of Medicine, University of the Witwatersrand, Johannesburg.

by RTT Staff Writer

For comments and feedback: editorial@rttnews.com

Business News

Quick Facts

Editors Pick
Sony announced Wednesday a temporary discount for the PlayStation 4, the same offer that was available on Black Friday and Cyber Monday. Starting December 11 and until December 24, the Japanese electronics maker will sell the Uncharted 4 PS4 Slim bundle for only $249.99 in the United States. A little over two months after reporting positive results from its first late-stage psoriasis trial, Dermira Inc. (DERM) is back with some more good news for its investors. Tata Steel UK announced that it has reached deal with the trade unions regarding a proposal to close the British Steel Pension Scheme to future accrual. The company also guaranteed investments and employment. The company said it will next week start consultation with its employees regarding the pension scheme closure. Instead, employees would be offered a competitive defined contribution scheme.
comments powered by Disqus
Follow RTT