logo
Plus   Neg
Share
Email

Agenus Says Phase 2 Study Of Brain Cancer Vaccine Shows Improved Survival

Biotechnology company Agenus Inc. (AGEN) Monday said a Phase 2 study result showed that more than 90 percent of aggressive brain cancer patients treated with Prophage Series G-200 were alive at six months after surgery and 30 percent were alive at twelve months.

Agenus said the next phase of development is underway with an NCI funded, large-scale, randomized trial investigating Prophage Series G-200 in combination with Avastin(bevacizumab). Avastin is approved for the treatment of recurrent Glioblastoma multiforme or GBM.

The shares are up more than 30 percent in pre-market trading.

"Glioblastoma tumors are often resistant to standard therapies and the extended survival observed in patients treated with Prophage Series vaccine is very promising," said Andrew Parsa, corresponding author of the study and chair of neurological surgery at Northwestern Memorial Hospital and Michael Marchese Professor and chair of the department of neurological surgery at the Feinberg School of Medicine at Northwestern University.

Agenus develops novel immune system activating treatments for cancers and infectious diseases. According to the company, the primary objective of this multi-center, single arm Phase 2 trial was to assess the survival rate at six months.

The Phase 2 trial enrolled 41 patients, with a mean age of 55 years, with surgically resectable recurrent high-grade GBM, the deadliest form of brain cancer.

The company noted that the median overall survival was about eleven months. This compares favorably to the expected median survival for recurrent GBM patients of three to nine months.

The data was published in a manuscript in Neuro-Oncology, the official journal of the Society of Neuro-Oncology.

GBM is the most common and most aggressive form of primary brain cancer. Despite approved therapy, patients with GBM face a poor prognosis. Prophage Series vaccines are currently being studied in both newly diagnosed and recurrent GBM.

Prophage Series vaccines are individualized cancer vaccines. Each Prophage Series vaccine is manufactured using a patient's own tumor after surgical removal.

Each vaccine contains the 'antigenic fingerprint' of the patient's particular cancer and is designed to activate the patient's immune system to specifically target and destroy cancer cells bearing this fingerprint.

AGEN closed Friday's regular trading at $2.44 on the Nasdaq. In the pre-market activity, the shares are up 30.33 percent.

For comments and feedback contact: editorial@rttnews.com

Business News

Editors Pick
Shares of General Electric Co. are rising more than 10 percent on Thursday after the industrial conglomerate said it plans to establish a new, independent company focused on building a comprehensive Industrial Internet of Things or IIoT software portfolio. In addition, longtime bearish analyst Stephen Tusa of J.P. Morgan upgraded shares of GE to neutral. Apple Inc. said Thursday that it will invest $1 billion to build a new corporate campus in North Austin that will eventually create 15,000 jobs. Further, the tech giant announced plans to establish new offices and expand to over 1,000 employees each in three cities - Seattle, San Diego and Culver City, California. In January, Apple said it will create over 20,000 jobs over the next five years. German telecom giant Deutsche Telekom, Chinese conglomerate Alibaba's Alibaba Cloud, banking giant Citi and 13 other organizations have joined Hyperledger Blockchain project, an open source collaborative effort aimed to advance cross-industry blockchain technologies. Hyperledger, a project of The Linux Foundation that started less than three years ago, is a multi-project.
Follow RTT