Regeneron Pharmaceuticals, Inc. (REGN) on Friday announced results from its Phase 3 trial evaluating Fianlimab, a LAG-3 inhibitor studied in combination with Cemiplimab for first-line unresectable or metastatic melanoma who have not received prior systemic therapy.
Phase 3 Trial of Fianlimab
The randomized, double-blind study enrolled more than 1,500 patients with unresectable locally advanced or metastatic melanoma who had not received prior systemic therapy. Patients were treated with either high-dose Fianlimab plus Cemiplimab, low-dose Fianlimab plus Cemiplimab, pembrolizumab monotherapy, Cemiplimab monotherapy.
The trial did not reach statistical significance for the primary endpoint of progression-free survival compared to pembrolizumab. However, a numeric improvement of 5.1 months in median progression-free survival was observed with the high-dose Fianlimab combination. Importantly, no new safety signals were identified.
Regeneron stated that detailed data will be presented at an upcoming medical meeting. In addition, a separate Phase 3 head-to-head trial of the high-dose Fianlimab combination versus Opdualag (nivolumab and relatlimab-rmbw) is ongoing.
REGN has traded between $476.49 and $821.11 over the past year. The stock closed Friday's trading (May 15, 2026) at $698.25, down 2.05%. During overnight trading, the stock is at $654.75, down 6.23%.
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May 15, 2026 15:25 ET Apart from the confirmation of Kevin Warsh as the next Fed chair, the main news on the economics front this week included key price data from the U.S. and the first quarter economic growth figures from major economies. Both consumer prices and producer costs have started to reflect the effect of supply shocks due to the Middle East conflict. In Europe, GDP data was in focus, while inflation data from China dominated the news flow in Asia.