Cytori Therapeutics Inc., (CYTX) reported results from a preclinical cell-enriched fat grafting study supporting the safety and efficacy of Cytori's method for enriching fat grafts with adipose-derived regenerative cells or ADRCs. The study tracked the expression of important growth factors within the cell-enriched fat grafts and examined the time course of the effect of ADRCs in a transplanted graft and the temporal role of growth factor expression. The results were presented today at the 32nd Annual CTRC-AACR San Antonio Breast Cancer Symposium.
The study results demonstrate that the ADRCs used to enrich the fat grafts were active for several days after implantation and secreted several growth factors within the fat grafts. Gene expression for the specific growth factors associated with the restoration and repair of blood vessels was initially very high but subsided to undetectable levels after three weeks.
The results suggest that the efficacy of the ADRCs may be due in part to their ability to secrete multiple important growth factors locally within the graft. In addition, the subsequent down regulation of these growth factors has positive long-term safety implications since continued, high level expression of these growth factors may not be desirable.
Overall, the initial local secretion of growth factors by ADRCs, followed by the rapid reduction in growth factor levels supports Cytori's proposed mechanism of action, i.e. the transplanted cells swiftly impart regenerative benefit and then become quiescent.
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