Tuesday, QLT Inc. (QLTI, QLT.TO) revealed positive twelve-month primary analysis results from the Phase II Radical study evaluating Visudyne-Lucentis combination therapy in patients with wet age-related macular degeneration, a medical condition usually of older adults, which results in a loss of vision in the center of the visual field.
The study was to determine if Visudyne combined with Lucentis reduces retreatment rates compared with Lucentis monotherapy, while maintaining similar vision outcomes and an acceptable safety profile. Three Visudyne-Lucentis combination therapies were evaluated against Lucentis monotherapy.
The company said the overall results showed that fewer retreatment visits were required with the combination therapies than with Lucentis monotherapy, and the differences were statistically significant. Of the four treatment groups, the triple therapy half-fluence group demonstrated the best results, with the fewest retreatment visits and mean visual acuity improvement most similar to Lucentis monotherapy through 12 months.
QLT revealed that the results for secondary VA endpoints in the Radical study were consistent with the primary VA endpoint. Ocular adverse events considered associated with treatment was reported for 33% of patients in the combination therapy groups, compared with 27% of patients in the Lucentis monotherapy group. The higher incidence of these events with combination therapy is primarily due to vision disturbance events, which are transient and known to be associated with Visudyne therapy.
QLT is currently trading at $2.47 up $0.12, or 5.11% on a volume of 0.18 million shares on the Nasdaq.
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