Gilead Sciences, Inc. (GILD) and Novo Nordisk A/S (NOVO B) Thursday said the companies have expanded their clinical collaboration in non-alcoholic steatohepatitis or NASH, a chronic and progressive liver disease that causes fat accumulation and inflammation in the liver that impairs liver function.
NASH is a potentially life-threatening disease condition with a high unmet medical need, as no drugs are currently approved to treat this.
The companies will investigate the safety and efficacy of Novo Nordisk's semaglutide, a GLP-1 receptor agonist, and a fixed-dose combination of Gilead's investigational FXR agonist cilofexor and investigational ACC inhibitor firsocostat, alone and in combination in people with compensated cirrhosis due to NASH.
The new Phase 2b study is based on positive results from a Phase 2a proof-of-concept study in 108 people with NASH and mild to moderate fibrosis. The study using cilofexor and/or firsocostat met a primary endpoint and was well tolerated.
The four-arm study will enroll around 440 patients will evaluate the treatments' impact on liver fibrosis improvement and NASH resolution.
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May 15, 2026 15:25 ET Apart from the confirmation of Kevin Warsh as the next Fed chair, the main news on the economics front this week included key price data from the U.S. and the first quarter economic growth figures from major economies. Both consumer prices and producer costs have started to reflect the effect of supply shocks due to the Middle East conflict. In Europe, GDP data was in focus, while inflation data from China dominated the news flow in Asia.