The following are some of the stocks making big moves in Wednesday's pre-market trading (as of 07.30 A.M. ET).
In the Green
iBio, Inc. (IBIO) is up over 86% at $2.14.Nuvation Bio Inc. (NUVB) is up over 21% at $3.50.PaySign, Inc. (PAYS) is up over 20% at $4.06.Hitek Global Inc. (HKIT) is up over 19% at $1.70.The ONE Group Hospitality, Inc. (STKS) is up over 15% at $4.64.BriaCell Therapeutics Corp. (BCTX) is up over 11% at $2.82.Trump Media & Technology Group Corp. (DJT) is up over 10% at $63.80.Ranpak Holdings Corp. (PACK) is up over 10% at $8.74.Bragg Gaming Group Inc. (BRAG) is up over 9% at $5.81.MediciNova, Inc. (MNOV) is up over 8% at $1.48.NeuroSense Therapeutics Ltd. (NRSN) is up over 7% at $1.83.Universe Pharmaceuticals INC (UPC) is up over 5% at $1.90.
In the Red
Direct Digital Holdings, Inc. (DRCT) is down over 44% at $14.77.LuxUrban Hotels Inc. (LUXH) is down over 20% at $1.71.GameStop Corp. (GME) is down over 17% at $12.84.Mesoblast Limited (MESO) is down over 14% at $3.37.Forge Global Holdings, Inc. (FRGE) is down over 10% at $2.36.BYND Cannasoft Enterprises Inc. (BCAN) is down over 8% at $1.43.Psyence Biomedical Ltd. (PBM) is down over 7% at $1.04.Organigram Holdings Inc. (OGI) is down over 6% at $2.51.Check-Cap Ltd. (CHEK) is down over 6% at $2.30.
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Business News
May 22, 2026 14:46 ET Minutes of the latest Fed policy session was the highlight of the week along with survey data on the U.S. housing market. In Europe, survey data signaled the trends in the euro area private sector. Further, consumer price inflation data from the U.K. was in focus. In Asia, various economic indicators from China drew attention to the health of the economy.